Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Radiology, Inje University Haeundae Paik Hospital, Busan, Korea.
Medicine (Baltimore). 2022 Jul 8;101(27):e29547. doi: 10.1097/MD.0000000000029547.
This study aimed to compare the background echotexture (BE) between automated breast ultrasound (ABUS) and handheld breast ultrasound (HHUS) and evaluate the correlation of BE with mammographic (MG) density and background parenchymal enhancement (BPE) on magnetic resonance imaging (MRI). A total of 212 women with newly diagnosed breast cancer who had undergone preoperative ABUS, HHUS, MG, and MRI were included. Two breast radiologists blinded to the menopausal status analyzed the BE of the contralateral breasts of the patients with breast cancer in consensus. The MG density and BPE of breast MRI on the radiologic reports were compared with the BE in the ultrasound. We used the cumulative link mixed model to compare the BE and Spearman rank correlation to evaluate the association between BE with MG density and BPE. BE was more heterogeneous in ABUS than in HHUS (P < .001) and in the premenopausal group than in the postmenopausal group (P < .001). The heterogeneity of BE in the premenopausal group was higher with ABUS than with HHUS (P = .013). BE and MG density showed a moderate correlation in the postmenopausal group, but a weak correlation in the premenopausal group. BE and BPE showed moderate correlations only in the premenopausal group. ABUS showed a more heterogeneous BE, especially in the premenopausal group. Therefore, more attention is required to interpret ABUS screening in premenopausal women.
本研究旨在比较自动乳腺超声（ABUS）和手持乳腺超声（HHUS）的背景回声纹理（BE），并评估 BE 与乳腺 X 线摄影（MG）密度和磁共振成像（MRI）上的背景实质增强（BPE）的相关性。共纳入 212 名新诊断为乳腺癌的女性患者，这些患者术前均接受了 ABUS、HHUS、MG 和 MRI 检查。两名乳腺放射科医生在不知道患者绝经状态的情况下对乳腺癌患者对侧乳房的 BE 进行了盲法分析。MG 密度和乳腺 MRI 的 BPE 在放射学报告上与超声中的 BE 进行了比较。我们使用累积链接混合模型来比较 BE，并用 Spearman 秩相关来评估 BE 与 MG 密度和 BPE 的相关性。ABUS 中的 BE 比 HHUS 更不均匀（P<0.001），且在绝经前组比绝经后组更不均匀（P<0.001）。绝经前组中 ABUS 的 BE 不均匀性高于 HHUS（P=0.013）。BE 与 MG 密度在后绝经组中呈中度相关性，但在前绝经组中呈弱相关性。仅在前绝经组中，BE 和 BPE 显示出中度相关性。ABUS 显示出更不均匀的 BE，尤其是在前绝经组。因此，在解释绝经前妇女的 ABUS 筛查时需要更加注意。
