Lysenko Elena S, Bogdanova Mariia D, Arsalidou Marie
Neurobiological Foundations of Cognitive Development - Neuropsy Lab, HSE University, 101000, Myasnitskaya st.-20, Moscow, Russian Federation.
I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991, Trubetskaya st.-8/2, Moscow, Russian Federation.
Neuropsychol Rev. 2023 Jun;33(2):459-473. doi: 10.1007/s11065-022-09546-3. Epub 2022 Jul 8.
Pediatric-onset multiple sclerosis (POMS), is the manifestation of multiple sclerosis in individuals before 18 years of age. About a third of children with POMS show some form of lower cognitive performance. The purpose of this study is to examine using quantitative meta-analyses the effect size of altered performance between children with and without POMS on overall intelligence quotient (IQ), information processing speed, and language functions. We searched the literature for studies that reported scores on cognitive tests administered to children with and without POMS. Studies were systematically reviewed using PRISMA guidelines. We analyzed data from 14 studies that examined 1283 children with and without POMS when cognitive categories consisted of five or more studies. Effect sizes, publication bias and potential confounds were considered. Significant cognitive differences are revealed for all categories with the strongest effect observed for overall IQ. A moderate effect is observed for information processing speed, and small effects for verbal fluency and verbal memory. Cognitive abilities present differently in children with POMS and a better understanding of this manifestation will inform intervention and remediation tools that can improve clinical and educational practice for the benefit of children with POMS.
儿童期多发性硬化症（POMS）是指多发性硬化症在18岁之前个体中的表现。约三分之一的POMS患儿表现出某种形式的认知能力下降。本研究的目的是通过定量荟萃分析，检验患有和未患有POMS的儿童在整体智商（IQ）、信息处理速度和语言功能方面表现改变的效应大小。我们在文献中搜索了报告对患有和未患有POMS的儿童进行认知测试分数的研究。使用PRISMA指南对研究进行系统综述。当认知类别由五项或更多研究组成时，我们分析了14项研究的数据，这些研究共涉及1283名患有和未患有POMS的儿童。考虑了效应大小、发表偏倚和潜在混杂因素。所有类别均显示出显著的认知差异，其中整体智商的效应最强。信息处理速度观察到中等效应，言语流畅性和言语记忆观察到小效应。POMS患儿的认知能力表现不同，更好地理解这种表现将为干预和补救工具提供依据，从而改善临床和教育实践，造福POMS患儿。
