Department of Histopathology, College of Medical Sciences, Abubakar Tafawa Balewa University, Bauchi, 7204212, Nigeria.
Departent of Pathology, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria.
Int Ophthalmol. 2022 Dec;42(12):3905-3911. doi: 10.1007/s10792-022-02411-5. Epub 2022 Jul 8.
Ocular surface squamous neoplasia (OSSN) is a heterogeneous group of proliferative squamous lesions on the ocular surface with varying biologic behaviours. This study aims to report the clinical profile and pathological characteristics of cases of OSSN seen at a tertiary referral centre in North West Nigeria.
A retrospective review of all cases of OSSN diagnosed over a 10-year period was done.
OSSN accounted for 68 out of 91 ocular surface lesions affecting twice as many males as females and a peak incidence in the 30-39 years age group. They frequently presented as higher-grade and higher-stage lesions with invasive squamous cell carcinoma being the most frequently diagnosed OSSN. They also frequently showed an association with HIV infection and a relatively long duration of symptoms before presentation.
OSSN occurs in a relatively young age group in our environment. Certain clinical and epidemiological features appear to predict the occurrence of higher-grade lesions, and this may help in the clinical prediction of likely pathologic grade and/or biologic behaviour of these lesions.
眼表鳞状上皮肿瘤（OSSN）是一组发生在眼表面的具有不同生物学行为的异质性增殖性鳞状病变。本研究旨在报告在尼日利亚西北部一家三级转诊中心就诊的 OSSN 病例的临床特征和病理特征。
对 10 年来所有 OSSN 诊断病例进行回顾性分析。
OSSN 占 91 例眼表病变中的 68 例，男性是女性的两倍，发病高峰在 30-39 岁年龄组。它们常表现为高级别和高分期病变，最常见的 OSSN 是侵袭性鳞状细胞癌。它们还常与 HIV 感染有关，且在就诊前症状持续时间相对较长。
在我们的环境中，OSSN 发生在相对年轻的年龄组。某些临床和流行病学特征似乎可以预测高级别病变的发生，这可能有助于临床预测这些病变的可能病理分级和/或生物学行为。
