Manzi L
Minerva Med. 1978 Sep 15;69(42):2889-92.
An unpublished letter written by Maurizio Bufalini on 8th January 1820 describes a clinical case of considerable gravity characterized by asthma with pleural effusion and "dilatation of the vena cava". On this basis, the state of knowledge of asthma in that period, particularly in relation to heart diseases, is reviewed. Following a careful examination of the letter, the possibility that M. Bufalini may have been a forerunner of the modern concept of cor pulmonale is suggested.
毛里齐奥·布法利尼于1820年1月8日写的一封未发表的信描述了一个病情相当严重的临床病例，其特征为哮喘伴胸腔积液和“腔静脉扩张”。在此基础上，回顾了那个时期对哮喘的认识状况，特别是与心脏病相关的认识。在仔细研究这封信之后，有人提出毛里齐奥·布法利尼可能是现代肺心病概念先驱的可能性。
