Department of Internal Medicine, Mayo Clinic, Phoenix, Arizona.
Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida.
Clin Adv Hematol Oncol. 2022 Jul;20(7):444-455.
The analysis of circulating tumor DNA (ctDNA) has multiple uses in oncology. In the past few years, studies with varying designs, methods, and quality have emerged that show promise for the use of ctDNA as a tool to detect minimal residual disease (MRD) across luminal gastrointestinal malignancies. This review of the current literature looks at ctDNA in relation to detecting MRD, predicting patient prognosis, and assessing risk for recurrence.
循环肿瘤 DNA（ctDNA）分析在肿瘤学中有多种用途。在过去几年中，出现了一些设计、方法和质量各不相同的研究，这些研究表明 ctDNA 作为一种工具用于检测腔道胃肠道恶性肿瘤的微小残留疾病（MRD）具有一定的前景。本文对当前文献进行综述，探讨了 ctDNA 在检测 MRD、预测患者预后和评估复发风险方面的应用。
