Department of Biochemistry and Molecular Biology, The Life Sciences Institute, The University of British Columbia, Vancouver, BC, Canada.
Department of Biochemistry and Molecular Biology, The Life Sciences Institute, The University of British Columbia, Vancouver, BC, Canada.
Structure. 2022 Jul 7;30(7):919-921. doi: 10.1016/j.str.2022.05.022.
In this issue of Structure, Melville and colleagues used cryo-EM to study the binding of ryanodine receptors to Rycals, compounds with the potential to treat skeletal and cardiac muscle disorders. Unexpectedly, they found that Rycal packs against an ATP in a peripheral pocket, which stabilizes the closed channel state.
在本期《结构》中，Melville 及其同事使用 cryo-EM 研究了 Ryanodine 受体与 Rycals 的结合，Rycals 是一种具有治疗骨骼肌和心肌疾病潜力的化合物。出乎意料的是，他们发现 Rycal 与一个 ATP 结合在一个外围口袋中，这稳定了关闭的通道状态。
