Institute for Clinical Transfusion Medicine and Immunogenetics, D-89081 Ulm, Germany.
Division of Cellular Immunology, German Cancer Research Center, D-69120 Heidelberg, Germany.
Cell. 2022 Jul 7;185(14):2398-2400. doi: 10.1016/j.cell.2022.06.026.
Thymus epithelial cells (TECs) express antigens from peripheral tissues to select against autoreactive T cells and thus prevent autoimmunity. Michelsen et al. now show that molecularly defined clusters of thymic epithelial cells express and depend on skin-, lung-, liver- or intestinal-cell transcription factors that are co-opted by the thymus to drive ectopic gene expression.
胸腺上皮细胞 (TEC) 表达来自外周组织的抗原，以选择自身反应性 T 细胞，从而防止自身免疫。Michelsen 等人现在表明，分子定义的胸腺上皮细胞簇表达并依赖于皮肤、肺、肝或肠道细胞转录因子，这些转录因子被胸腺篡夺来驱动异位基因表达。
