Davidson T, Kissin M, Westbury G
Br J Obstet Gynaecol. 1987 May;94(5):473-6. doi: 10.1111/j.1471-0528.1987.tb03128.x.
A total of 32 patients presenting with melanoma of the vulva and vagina over a 20-year period was reviewed. Primary surgical treatment was by local excision in 14 patients, simple vulvectomy in seven patients and radical resection in 11 patients. Overall 5-year survival was 25% and only one patient was alive at 10 years. Comparison between the groups showed no benefit either in local control, disease-free interval or patient survival according to extent of primary resection. We suggest that, as in anorectal melanoma, radical resection of the primary lesion is unlikely to alter the extremely grave prognosis and its routine use should be abandoned.
回顾了20年间共32例外阴和阴道黑色素瘤患者。14例患者接受局部切除作为主要手术治疗，7例患者接受单纯外阴切除术，11例患者接受根治性切除术。总体5年生存率为25%，仅1例患者存活至10年。组间比较显示，根据原发灶切除范围，在局部控制、无病生存期或患者生存率方面均无益处。我们建议，与肛管直肠黑色素瘤一样，原发灶的根治性切除不太可能改变极其严重的预后，应放弃常规使用。
