Karma A, Poukkula A A, Ruokonen A O
Br J Ophthalmol. 1987 May;71(5):361-7. doi: 10.1136/bjo.71.5.361.
Gallium (67Ga) citrate uptake over the orbits, parotid glands, and lungs was examined in six newly detected patients with sarcoidosis and 17 with chronic sarcoidosis. Six of 23 (26%) had uveitis, 18/23 (78%) decreased lacrimal secretion, and 13/16 (81%) epithelioid cell granulomas in conjunctival biopsies. Ten patients with other diseases served as controls. Only five patients had ocular complaints and two had enlarged parotid glands. 67Ga uptake over the orbits and parotids was measured by a quantitative computer based method. Gallium uptake was significantly higher over the orbits (p less than 0.001) and parotids (p less than 0.01) in the newly detected patients and in the parotids (p less than 0.01) in the chronic group than the corresponding uptake in the controls. We suggest that in sarcoidosis an increased 67Ga uptake in the orbital and parotid areas may be a phenomenon comparable to an increased 67Ga uptake in the lungs in active alveolitis. Gallium scan is a good method for revealing even symptomless ophthalmic sarcoid changes. However, in chronic sarcoidosis an equal or only slightly increased gallium uptake over the orbits compared with background activity does not exclude ocular sarcoid disease.
对6例新诊断的结节病患者和17例慢性结节病患者的眼眶、腮腺和肺部的枸橼酸镓（67Ga）摄取情况进行了检查。23例患者中有6例（26%）患有葡萄膜炎，18/23例（78%）泪液分泌减少，13/16例（81%）结膜活检发现上皮样细胞肉芽肿。10例患有其他疾病的患者作为对照。只有5例患者有眼部不适，2例腮腺肿大。通过基于计算机的定量方法测量眼眶和腮腺的67Ga摄取量。新诊断患者眼眶（p<0.001）和腮腺（p<0.01）以及慢性组腮腺（p<0.01）的镓摄取量显著高于对照组的相应摄取量。我们认为，在结节病中，眼眶和腮腺区域67Ga摄取增加可能是一种与活动性肺泡炎中肺部67Ga摄取增加类似的现象。镓扫描是发现即使无症状的眼部结节病改变的一种好方法。然而，在慢性结节病中，与背景活性相比，眼眶镓摄取量相等或仅略有增加并不能排除眼部结节病。
