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1
Omalizumab is associated with improved asthma outcomes in children and adolescents with serum immunoglobulin E above dosing guidelines.对于血清免疫球蛋白E高于给药指南的儿童和青少年，奥马珠单抗与改善哮喘预后相关。
J Allergy Clin Immunol Pract. 2022 Oct;10(10):2756-2757.e1. doi: 10.1016/j.jaip.2022.06.041. Epub 2022 Jul 5.
2
The statement of the Polish Society of Allergology regarding necessary changes in therapeutic program of severe IgE-mediated allergic asthma with omalizumab.波兰变态反应学会关于使用奥马珠单抗治疗严重IgE介导的过敏性哮喘的治疗方案必要变更的声明。
Pneumonol Alergol Pol. 2015;83(4):335-8. doi: 10.5603/PiAP.2015.0053.
3
Long-term course of serum total and free IgE levels in severe asthma patients treated with omalizumab.接受奥马珠单抗治疗的重度哮喘患者血清总IgE和游离IgE水平的长期病程
Allergol Int. 2018 Apr;67(2):283-285. doi: 10.1016/j.alit.2017.08.003. Epub 2017 Sep 18.
4
'Real-life' experience in asthmatic children treated with omalizumab up to six-years follow-up.接受奥马珠单抗治疗的哮喘儿童长达六年的随访“真实生活”经验。
Allergol Immunopathol (Madr). 2019 Jul-Aug;47(4):336-341. doi: 10.1016/j.aller.2018.09.009. Epub 2018 Nov 30.
5
Omalizumab in Japanese children with severe allergic asthma uncontrolled with standard therapy.奥马珠单抗用于标准治疗无法控制的日本重度过敏性哮喘儿童。
Allergol Int. 2015 Oct;64(4):364-70. doi: 10.1016/j.alit.2015.05.006. Epub 2015 Jun 10.
6
Efficacy and effectiveness of omalizumab in the treatment of childhood asthma.奥马珠单抗治疗儿童哮喘的疗效和有效性。
Expert Rev Respir Med. 2018 Sep;12(9):745-754. doi: 10.1080/17476348.2018.1507740. Epub 2018 Aug 28.
7
Effects of omalizumab in children with asthma: A protocol for systematic review and meta-analysis.奥马珠单抗治疗哮喘儿童的效果：系统评价和荟萃分析方案。
Medicine (Baltimore). 2021 Jun 4;100(22):e26155. doi: 10.1097/MD.0000000000026155.
8
The discovery and development of omalizumab for the treatment of asthma.用于治疗哮喘的奥马珠单抗的发现与研发。
Expert Opin Drug Discov. 2015;10(9):1033-42. doi: 10.1517/17460441.2015.1048220. Epub 2015 May 15.
9
Eosinophilic Esophagitis Onset Despite Six Years' Treatment With Omalizumab in an Asthmatic Patient: No Protective Effect for Anti-IgE Therapy?一名哮喘患者接受奥马珠单抗治疗六年仍发生嗜酸性食管炎：抗IgE治疗无保护作用？
Am J Gastroenterol. 2021 Jul 1;116(7):1560. doi: 10.14309/ajg.0000000000001213.
10
Reduction of the total immunoglobulin E level by omalizumab in children and adolescents.奥马珠单抗降低儿童和青少年的总免疫球蛋白E水平。
J Asthma. 2010 Sep;47(7):832-3. doi: 10.3109/02770903.2010.487144.

本文引用的文献

1
Real-World Effectiveness of Omalizumab in Severe Allergic Asthma: A Meta-Analysis of Observational Studies.奥马珠单抗治疗重度过敏性哮喘的真实世界疗效：一项观察性研究的荟萃分析。
J Allergy Clin Immunol Pract. 2021 Jul;9(7):2702-2714. doi: 10.1016/j.jaip.2021.01.011. Epub 2021 Jan 21.
2
Efficacy and safety of omalizumab in pediatric patients with high immunoglobulin E levels: A case series.奥马珠单抗在高免疫球蛋白E水平儿科患者中的疗效与安全性：病例系列
Allergy Asthma Proc. 2018 Jul 1;39(4):289-291. doi: 10.2500/aap.2018.39.4146.
3
The Economic Burden of Asthma in the United States, 2008-2013.美国 2008-2013 年哮喘经济负担
Ann Am Thorac Soc. 2018 Mar;15(3):348-356. doi: 10.1513/AnnalsATS.201703-259OC.
4
Omalizumab in children with uncontrolled allergic asthma: Review of clinical trial and real-world experience.奥马珠单抗治疗未控制的过敏性哮喘儿童：临床试验和真实世界经验的综述。
J Allergy Clin Immunol. 2017 May;139(5):1431-1444. doi: 10.1016/j.jaci.2017.03.002.
5
Real-life effectiveness of omalizumab in severe allergic asthma above the recommended dosing range criteria.奥马珠单抗在高于推荐剂量范围标准的重度过敏性哮喘中的实际疗效。
Clin Exp Allergy. 2016 Nov;46(11):1407-1415. doi: 10.1111/cea.12774. Epub 2016 Jul 22.
6
Omalizumab in patients with allergic (IgE-mediated) asthma and IgE/bodyweight combinations above those in the initially approved dosing table.奥马珠单抗用于治疗过敏性（IgE介导）哮喘且IgE/体重组合高于最初批准剂量表中的患者。
Pulm Pharmacol Ther. 2014 Aug;28(2):149-53. doi: 10.1016/j.pupt.2014.03.003. Epub 2014 Mar 18.
7
Reassessment of omalizumab-dosing strategies and pharmacodynamics in inner-city children and adolescents.评估城市内儿童和青少年奥马珠单抗的剂量策略和药效学。
J Allergy Clin Immunol Pract. 2013 Mar;1(2):163-71. doi: 10.1016/j.jaip.2013.01.011. Epub 2013 Feb 26.
8
Efficacy of omalizumab in asthmatic patients with IgE levels above 700 IU/mL: a retrospective study.奥马珠单抗治疗 IgE 水平高于 700 IU/mL 的哮喘患者的疗效：一项回顾性研究。
Ann Allergy Asthma Immunol. 2013 Jun;110(6):457-61. doi: 10.1016/j.anai.2013.04.011.
9
Add-on omalizumab in children with severe allergic asthma: a 1-year real life survey.重度过敏性哮喘患儿奥马珠单抗附加治疗：一项为期 1 年的真实世界调查。
Eur Respir J. 2013 Nov;42(5):1224-33. doi: 10.1183/09031936.00149812. Epub 2013 Mar 21.

Omalizumab is associated with improved asthma outcomes in children and adolescents with serum immunoglobulin E above dosing guidelines.

作者信息

Atkinson Claire E, Schworer Stephen A, Matthews Kate, Mills Katherine, Neighbors Katherine, Burbank Allison J, Hernandez Michelle L

机构信息

Division of Allergy & Immunology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC.

Division of Infectious Disease, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC.

出版信息

J Allergy Clin Immunol Pract. 2022 Oct;10(10):2756-2757.e1. doi: 10.1016/j.jaip.2022.06.041. Epub 2022 Jul 5.

DOI:10.1016/j.jaip.2022.06.041
PMID:35803538
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10519372/
Abstract
摘要