Plastic Surgeon, A.C. Camargo Cancer Center, São Paulo, SP, Brazil.
Department of Cutaneous Oncology, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
An Bras Dermatol. 2022 Sep-Oct;97(5):583-591. doi: 10.1016/j.abd.2021.09.013. Epub 2022 Jul 5.
Basal cell and squamous cell carcinomas (BCC and SCC) are the most common types of cancer worldwide. Intraoperative assessment of surgical margins by frozen section has been widely used to ensure disease-free margins. The intraoperative "en face" freezing technique evaluates all peripheral and deep margins.
To report the results of the "en face" freezing technique in relation to tumor recurrence and agreement with paraffin-embedded tissue examination.
Retrospective analysis of patients undergoing surgical excision of BCC and SCC at the A. C. Camargo Cancer Center, Brazil.
This study included 542 skin carcinomas, which were excised from 397 patients. A total of 201 male patients (50.6%), and 196 female patients (49.4%) were assessed, whose mean age was 64 years. The tumors were mostly located on the head and neck region (87.8%). BCC corresponded to 79.7% of the cases. The mean follow-up was 38 months. Tumor relapse occurred in 0.86% of the primary tumors and 3.7% of recurrent tumors. The result of the intraoperative "en face" frozen section evaluation was in agreement with the final result of the anatomopathological examination (paraffin test) in 98% of the lesions.
Not having a minimum follow-up time of 5 years for all patients.
The "en face" freezing technique shows low tumor relapse, being reliable and safe to guarantee negative surgical margins of the tumor.
基底细胞癌和鳞状细胞癌（BCC 和 SCC）是全球最常见的癌症类型。术中通过冷冻切片评估手术切缘已被广泛用于确保无肿瘤切缘。术中“直面”冷冻技术评估所有周边和深部切缘。
报告“直面”冷冻技术在肿瘤复发方面的结果，并与石蜡包埋组织检查的结果进行比较。
对巴西 A. C. Camargo 癌症中心行 BCC 和 SCC 手术切除的患者进行回顾性分析。
本研究共纳入 542 例皮肤癌患者，来自 397 例患者。共评估了 201 名男性患者（50.6%）和 196 名女性患者（49.4%），平均年龄为 64 岁。肿瘤主要位于头颈部（87.8%）。BCC 占病例的 79.7%。平均随访时间为 38 个月。原发性肿瘤的肿瘤复发率为 0.86%，复发性肿瘤的复发率为 3.7%。术中“直面”冷冻切片评估结果与解剖病理学检查（石蜡试验）的最终结果一致，符合率为 98%。
并非所有患者的随访时间都不少于 5 年。
“直面”冷冻技术显示出较低的肿瘤复发率，可靠且安全，可确保肿瘤的阴性手术切缘。
