Hu Kan, Cheng Aoyuan, Zhou Dingcheng, Luo Yi, Zhang Guoqing
Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, 230026, China.
Macromol Rapid Commun. 2022 Oct;43(19):e2200124. doi: 10.1002/marc.202200124. Epub 2022 Jul 14.
Lipid nanovesicles (LNVs) and polymer nanovesicles (PNVs), also known as liposomes and polymersomes, are becoming increasingly vital in global health. However, the two major classes of nanovesicles both exhibit their own issues that significantly limit potential applications. Here, by covalently attaching a naturally occurring phosphate "lipid head" and a synthetic polylactide "polymer tail" via facile ring-opening polymerization on a 500 g scale, a type of "chimeric" nanovesicles (CNVs) can be easily produced. Compared to LNVs, the reported CNVs exhibit reduced permeability for small and large molecules; on the other hand, the CNVs are less hydrophobic and exhibit enhanced tolerance toward proteins in buffer solutions without the need for hydrophilic polymeric corona such as poly(ethylene glycol)(PEG), in contrast to conventional PNVs. The proof-of-concept in vitro delivery experiments using hydrophilic solutions of fluorescein-PEG, rhodamine-PEG, and anti-cancer drug doxorubicin demonstrate that these CNVs, as a structurally diverse class of nano-materials, are highly promising as alternative carriers for therapeutic molecules in translational nanomedicine.
脂质纳米囊泡（LNVs）和聚合物纳米囊泡（PNVs），也被称为脂质体和聚合物囊泡，在全球健康领域正变得越来越重要。然而，这两类主要的纳米囊泡都存在自身的问题，这些问题严重限制了它们的潜在应用。在此，通过在500克规模上经由简便的开环聚合反应将天然存在的磷酸“脂质头部”和合成的聚丙交酯“聚合物尾部”共价连接，一种“嵌合”纳米囊泡（CNVs）能够轻易制备出来。与LNVs相比，所报道的CNVs对小分子和大分子的渗透性降低；另一方面，与传统的PNVs不同，CNVs疏水性较低，并且在缓冲溶液中对蛋白质表现出更高的耐受性，无需诸如聚乙二醇（PEG）之类的亲水性聚合物冠层。使用荧光素 - PEG、罗丹明 - PEG的亲水性溶液以及抗癌药物阿霉素进行的概念验证体外递送实验表明，这些CNVs作为一类结构多样的纳米材料，在转化纳米医学中作为治疗性分子的替代载体具有很大的前景。
