[Inhibition of microsomal oxidation by o-benzoquinone derivatives].
作者信息
Kostiuk V A
出版信息
Biokhimiia. 1987 Mar;52(3):355-8.
PMID:3580408
Abstract
It was found that o-benzoquinone derivatives inhibit the hydroxylation of aniline without any appreciable influence on the spectral changes which are due to cytochrome P-450 binding to the substrate. A comparative kinetic study of inhibition of aniline hydroxylation and NADPH-dependent reduction of o-benzoquinones in liver microsomes revealed that the inhibition is due to the ability of these compounds to shunt microsomal electron transport pathways.
摘要
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