Meador-Woodruff J H, Gurguis G, Grunhaus L, Haskett R F, Greden J F
Biol Psychiatry. 1987 May;22(5):583-92. doi: 10.1016/0006-3223(87)90186-7.
The hypothalamic-pituitary-adrenal (HPA) axis is dysregulated in many patients with major depressive disorder (MDD). To determine whether or not a past history of depressive episodes is associated with this dysregulation, we studied the relationships among number of past depressive episodes, number of previous hospitalizations for depression, and number of years since first depressive episode and biological markers of depression (postdexamethasone plasma cortisol levels and dexamethasone suppressor/nonsuppressor status). No significant relationships were detected.
许多重度抑郁症（MDD）患者的下丘脑 - 垂体 - 肾上腺（HPA）轴失调。为了确定既往抑郁发作史是否与这种失调相关，我们研究了既往抑郁发作次数、既往因抑郁症住院次数、首次抑郁发作后的年数与抑郁的生物学标志物（地塞米松后血浆皮质醇水平和地塞米松抑制/非抑制状态）之间的关系。未检测到显著关系。
