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生长激素释放激素受体基因多态性对中国大别山牛体型性状的影响

Polymorphisms of the Growth Hormone Releasing Hormone Receptor Gene Affect Body Conformation Traits in Chinese Dabieshan Cattle.

作者信息

Zhao Shuanping, Jin Hai, Xu Lei, Jia Yutang

机构信息

Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei 230031, China.

出版信息

Animals (Basel). 2022 Jun 21;12(13):1601. doi: 10.3390/ani12131601.

DOI:10.3390/ani12131601
PMID:35804502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9265053/
Abstract

This study was performed to expose the polymorphisms of the growth hormone-releasing hormone receptor gene in Chinese Dabieshan cattle, evaluate its effect on body conformation traits, and find potential molecular markers in Chinese cattle. The GHRHR structure and the phylogenetic tree were analyzed using bioinformatics software. The polymorphism of the GHRHR gene in 486 female cattle was genotyped by PCR-RFLP and DNA sequencing, and the association between SNPs and body conformation traits of Chinese Dabieshan cattle was analyzed by one-way ANOVA in SPSS software. GHRHR was often conserved in nine species, and its sequence of cattle was closest to sheep and goats. Six polymorphic SNPs were identified, g.10667A > C and g.10670A > C were missense mutation. The association analysis indicated that the six SNPs significantly influenced the body conformation traits of Chinese Dabieshan cattle (p < 0.05). Six haplotypes were identified and Hap1 (-CAACGA-) had the highest frequency (36.10%). The Hap3/5 (-GCCCCCGGAAGG-) exhibited a significantly greater wither height (WH), hip height (HH), heart girth (HG), and hip width (HW) (p < 0.05). Overall, the polymorphisms of GHRHR affected the body conformation traits of Chinese Dabieshan cattle, and the GHRHR gene could be used as a molecular marker in Dabieshan cattle breeding programs.

摘要

本研究旨在揭示中国大别山牛生长激素释放激素受体基因的多态性，评估其对体躯形态性状的影响，并寻找中国牛潜在的分子标记。使用生物信息学软件分析了生长激素释放激素受体（GHRHR）的结构和系统发育树。通过PCR-RFLP和DNA测序对486头母黄牛的GHRHR基因多态性进行基因分型，并利用SPSS软件中的单因素方差分析方法分析了单核苷酸多态性（SNPs）与中国大别山牛体躯形态性状之间的关联。GHRHR在9个物种中通常较为保守，其牛的序列与绵羊和山羊最为接近。共鉴定出6个多态性SNPs，g.10667A > C和g.10670A > C为错义突变。关联分析表明，这6个SNPs显著影响中国大别山牛的体躯形态性状（p < 0.05）。鉴定出6种单倍型，其中单倍型1（-CAACGA-）频率最高（36.10%）。单倍型3/5（-GCCCCCGGAAGG-）的鬐甲高（WH）、臀高（HH）、胸围（HG）和臀宽（HW）显著更高（p < 0.05）。总体而言，GHRHR基因的多态性影响了中国大别山牛的体躯形态性状，GHRHR基因可作为大别山牛育种计划中的分子标记。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/9265053/22ed8b6aad84/animals-12-01601-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/9265053/2fd5be8c5065/animals-12-01601-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/9265053/1d6929247ace/animals-12-01601-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/9265053/e12ac8e92f75/animals-12-01601-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/9265053/3f0207aa20b8/animals-12-01601-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/9265053/016b90a989aa/animals-12-01601-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/9265053/22ed8b6aad84/animals-12-01601-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/9265053/2fd5be8c5065/animals-12-01601-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/9265053/1d6929247ace/animals-12-01601-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/9265053/e12ac8e92f75/animals-12-01601-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/9265053/3f0207aa20b8/animals-12-01601-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/9265053/016b90a989aa/animals-12-01601-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb61/9265053/22ed8b6aad84/animals-12-01601-g006.jpg

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本文引用的文献

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Genetic variants in MYF5 affected growth traits and beef quality traits in Chinese Qinchuan cattle.
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Signaling mechanisms of growth hormone-releasing hormone receptor in LPS-induced acute ocular inflammation.生长激素释放激素受体在脂多糖诱导的急性眼部炎症中的信号转导机制。
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InDels within caprine IGF2BP1 intron 2 and the 3'-untranslated regions are associated with goat growth traits.内源性缺失 within caprine IGF2BP1 内含子 2 和 3'-非翻译区与山羊生长性状相关。
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