Alkayyal Almohanad A
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.
Front Mol Biosci. 2025 May 22;12:1615393. doi: 10.3389/fmolb.2025.1615393. eCollection 2025.
Cancer is a complex disease affecting both humans and animals. Comparative immuno-oncology explores immune responses across species to develop effective cancer therapies. Oncolytic viruses (OVs) serve as both direct tumor-lysing agents and immune stimulants, making them an attractive therapeutic option. This review highlights the role of naturally occurring tumors in animal models for OV-based cancer immunotherapy. We examine immune responses in different species, the latest advancements in OV therapy, and the role of precision medicine in veterinary oncology. Understanding these comparative aspects enhances OV translation from preclinical to clinical applications in both veterinary and human oncology.
癌症是一种影响人类和动物的复杂疾病。比较免疫肿瘤学探索跨物种的免疫反应以开发有效的癌症治疗方法。溶瘤病毒（OVs）既是直接的肿瘤溶解剂又是免疫刺激剂，使其成为有吸引力的治疗选择。本综述强调了天然肿瘤在基于OV的癌症免疫治疗动物模型中的作用。我们研究了不同物种的免疫反应、OV治疗的最新进展以及精准医学在兽医肿瘤学中的作用。了解这些比较方面可增强OV从临床前到兽医和人类肿瘤学临床应用的转化。
