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NLRP3炎性小体在肝癌发生和治疗中的作用：利用固有免疫

The Role of the NLRP3 Inflammasome in HCC Carcinogenesis and Treatment: Harnessing Innate Immunity.

作者信息

Papadakos Stavros P, Dedes Nikolaos, Kouroumalis Elias, Theocharis Stamatios

机构信息

First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Department of Gastroenterology, Medical School, University of Crete, 71500 Heraklion, Greece.

出版信息

Cancers (Basel). 2022 Jun 27;14(13):3150. doi: 10.3390/cancers14133150.

DOI:10.3390/cancers14133150
PMID:35804922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9264914/
Abstract

The HCC constitutes one of the most frequent cancers, with a non-decreasing trend in disease mortality despite advances in systemic therapy and surgery. This trend is fueled by the rise of an obesity wave which is prominent the Western populations and has reshaped the etiologic landscape of HCC. Interest in the nucleotide-binding domain leucine-rich repeat containing (NLR) family member NLRP3 has recently been revived since it would appear that, by generating inflammasomes, it participates in several physiologic processes and its dysfunction leads to disease. The NLRP3 inflammasome has been studied in depth, and its influence in HCC pathogenesis has been extensively documented during the past quinquennial. Since inflammation comprises a major regulator of carcinogenesis, it is of paramount importance an attempt to evaluate the contribution of the NLRP3 inflammasome to the generation and management of HCC. The aim of this review was to examine the literature in order to determine the impact of the NLRP3 inflammasome on, and present a hypothesis about its input in, HCC.

摘要

肝细胞癌（HCC）是最常见的癌症之一，尽管在全身治疗和手术方面取得了进展，但疾病死亡率仍呈上升趋势。肥胖浪潮的兴起加剧了这一趋势，肥胖在西方人群中尤为突出，并重塑了HCC的病因格局。最近，人们对含核苷酸结合域富含亮氨酸重复序列（NLR）的家族成员NLRP3的兴趣再度燃起，因为它似乎通过生成炎性小体参与多种生理过程，其功能障碍会导致疾病。NLRP3炎性小体已得到深入研究，在过去五年中，其对HCC发病机制的影响已有大量文献记载。由于炎症是致癌作用的主要调节因素，因此评估NLRP3炎性小体对HCC发生和治疗的贡献至关重要。本综述的目的是查阅文献，以确定NLRP3炎性小体对HCC的影响，并提出关于其在HCC中作用的假说。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9297/9264914/d7925d0f89cb/cancers-14-03150-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9297/9264914/a92d7dfe3d52/cancers-14-03150-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9297/9264914/d7925d0f89cb/cancers-14-03150-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9297/9264914/a92d7dfe3d52/cancers-14-03150-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9297/9264914/d7925d0f89cb/cancers-14-03150-g002.jpg

相似文献

[1]
The Role of the NLRP3 Inflammasome in HCC Carcinogenesis and Treatment: Harnessing Innate Immunity.

Cancers (Basel). 2022-6-27

[2]
Activation of NLRP3 Inflammasome and Onset of Alzheimer's Disease.

Front Immunol. 2021

[3]
Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome in Cardiovascular Disorders.

Arterioscler Thromb Vasc Biol. 2018-12

[4]
Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung Disease.

Am J Respir Cell Mol Biol. 2016-2

[5]
NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy.

Acta Ophthalmol. 2017-12

[6]
Activated NLR family pyrin domain containing 3 (NLRP3) inflammasome in keratinocytes promotes cutaneous T-cell response in patients with vitiligo.

J Allergy Clin Immunol. 2019-11-19

[7]
The nucleotide-binding domain, leucine-rich repeat protein 3 inflammasome/IL-1 receptor I axis mediates innate, but not adaptive, immune responses after exposure to particulate matter under 10 μm.

Am J Respir Cell Mol Biol. 2015-1

[8]
E2-Induced Activation of the NLRP3 Inflammasome Triggers Pyroptosis and Inhibits Autophagy in HCC Cells.

Oncol Res. 2019-3-25

[9]
Expression of the NLRP3 inflammasome in cerebral cortex after traumatic brain injury in a rat model.

Neurochem Res. 2013-7-28

[10]
Mechanism and Regulation of NLRP3 Inflammasome Activation.

Trends Biochem Sci. 2016-12

引用本文的文献

[1]
Effect of abdominal aortic calcification on long-term outcomes after the first liver resection in very old patients with hepatocellular carcinoma.

Ann Gastroenterol Surg. 2024-6-22

[2]
NLRP3 inflammasome in atherosclerosis: Mechanisms and targeted therapies.

Front Pharmacol. 2024-7-31

[3]
Exploring the Role of GITR/GITRL Signaling: From Liver Disease to Hepatocellular Carcinoma.

Cancers (Basel). 2024-7-22

[4]
Ropivacaine synergizes with sorafenib to induce apoptosis of hepatocellular carcinoma cells via the IL-6/STAT3 pathway.

Cancer Sci. 2024-9

[5]
γδ T Cells: A Game Changer in the Future of Hepatocellular Carcinoma Immunotherapy.

Int J Mol Sci. 2024-1-23

[6]
Interplay of Extracellular Vesicles and TLR4 Signaling in Hepatocellular Carcinoma Pathophysiology and Therapeutics.

Pharmaceutics. 2023-10-13

[7]
Meeting at the Crossroad between Obesity and Hepatic Carcinogenesis: Unique Pathophysiological Pathways Raise Expectations for Innovative Therapeutic Approaches.

Int J Mol Sci. 2023-9-28

[8]
Exploring the JAK/STAT Signaling Pathway in Hepatocellular Carcinoma: Unraveling Signaling Complexity and Therapeutic Implications.

Int J Mol Sci. 2023-9-6

[9]
Unveiling the Yin-Yang Balance of M1 and M2 Macrophages in Hepatocellular Carcinoma: Role of Exosomes in Tumor Microenvironment and Immune Modulation.

Cells. 2023-8-10

[10]
Gender Differences in a Mouse Model of Hepatocellular Carcinoma Revealed Using Multi-Modal Imaging.

Cancers (Basel). 2023-7-26

本文引用的文献

[1]
Molecular pathogenesis and systemic therapies for hepatocellular carcinoma.

Nat Cancer. 2022-4

[2]
Emerging Roles of Inflammasomes in Cardiovascular Diseases.

Front Immunol. 2022

[3]
The Role of Inflammasomes in Glomerulonephritis.

Int J Mol Sci. 2022-4-11

[4]
Emerging Antiarrhythmic Drugs for Atrial Fibrillation.

Int J Mol Sci. 2022-4-7

[5]
Protection and Pathology in Infection.

Pathogens. 2022-4-14

[6]
Dual Effect of Immune Cells within Tumour Microenvironment: Pro- and Anti-Tumour Effects and Their Triggers.

Cancers (Basel). 2022-3-25

[7]
Hepatocellular carcinoma: The virus or the liver?

Liver Int. 2023-8

[8]
Neutrophil extracellular traps induce tumor metastasis through dual effects on cancer and endothelial cells.

Oncoimmunology. 2022

[9]
Inflammasome-Associated Gastric Tumorigenesis Is Independent of the NLRP3 Pattern Recognition Receptor.

Front Oncol. 2022-3-1

[10]
The role of the inflammasome and its related pathways in ovarian cancer.

Clin Transl Oncol. 2022-8

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