基质金属蛋白酶-13在癌症进展和转移中的调控与功能
Regulation and Function of Matrix Metalloproteinase-13 in Cancer Progression and Metastasis.
作者信息
Li Shun, Pritchard David Mark, Yu Lu-Gang
机构信息
Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK.
Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK.
出版信息
Cancers (Basel). 2022 Jul 3;14(13):3263. doi: 10.3390/cancers14133263.
Matrix metalloproteinase-13 (MMP-13) is a member of the Matrix metalloproteinases (MMPs) family of endopeptidases. MMP-13 is produced in low amounts and is well-regulated during normal physiological conditions. Its expression and secretion are, however, increased in various cancers, where it plays multiple roles in tumour progression and metastasis. As an interstitial collagenase, MMP-13 can proteolytically cleave not only collagens I, II and III, but also a range of extracellular matrix proteins (ECMs). Its action causes ECM remodelling and often leads to the release of various sequestered growth and angiogenetic factors that promote tumour cell growth, invasion and angiogenesis. This review summarizes our current understanding of the regulation of MMP-13 expression and secretion and discusses the actions of MMP-13 in cancer progression and metastasis.
基质金属蛋白酶-13（MMP-13）是内肽酶基质金属蛋白酶（MMPs）家族的成员之一。MMP-13在正常生理条件下产量较低且受到良好调控。然而，在各种癌症中其表达和分泌会增加，在肿瘤进展和转移中发挥多种作用。作为一种间质胶原酶，MMP-13不仅可以蛋白水解切割I型、II型和III型胶原蛋白，还能切割一系列细胞外基质蛋白（ECM）。其作用导致ECM重塑，并常常导致各种被隔离的生长因子和血管生成因子释放，从而促进肿瘤细胞生长、侵袭和血管生成。本综述总结了我们目前对MMP-13表达和分泌调控的理解，并讨论了MMP-13在癌症进展和转移中的作用。
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