Králíčková Milena, Fiala Ludek, Losan Petr, Tomes Pavel, Vetvicka Vaclav
a Department of Histology and Embryology, Faculty of Medicine , Charles University , Plzen , Czech Republic.
b Department of Obstetrics and Gynecology, University Hospital, Faculty of Medicine , Charles University , Plzen , Czech Republic.
Immunol Invest. 2018 Aug;47(6):569-582. doi: 10.1080/08820139.2018.1467926. Epub 2018 Jun 6.
This study was conducted to summarize current knowledge of the changes within the immune system, from action of macrophages, lymphocytes and NK cells to biological effects of their products. Endometriosis is a complex gynecological disorder defined as a presence of endometrial tissue outside the uterus affecting over 5 million reproductive-aged women in the U.S. alone.
In recent years, the potential role of the immune system in the development of endometriosis has increasingly gained attention. Data summarized in our study showed that the most relevant immunocytes are macrophages residing inside the peritoneal cavity and the ratios of Th1 to Th2 cells. Another crucial immunological parameter is the balance in production of cytokines and chemoatractants.
This review confirms that despite decades of intensive research, the involvement of the immune system remains elusive, as we can recognize the changes, but still do not understand if these changes represent the results of endometriosis or if they are contributing factors. Based on these findings, we also discuss new treatment possibilities.
本研究旨在总结免疫系统内从巨噬细胞、淋巴细胞和自然杀伤细胞的作用到其产物的生物学效应的当前知识。子宫内膜异位症是一种复杂的妇科疾病，定义为子宫外存在子宫内膜组织，仅在美国就影响着超过500万育龄妇女。
近年来，免疫系统在子宫内膜异位症发展中的潜在作用越来越受到关注。我们研究中总结的数据表明，最相关的免疫细胞是腹腔内的巨噬细胞以及Th1细胞与Th2细胞的比例。另一个关键的免疫学参数是细胞因子和趋化因子产生的平衡。
本综述证实，尽管经过数十年的深入研究，但免疫系统的参与情况仍然难以捉摸，因为我们能够识别这些变化，但仍不明白这些变化是子宫内膜异位症的结果还是促成因素。基于这些发现，我们还讨论了新的治疗可能性。
