Department of Psychiatry, Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.
Psychiatric Research Center, Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.
Int J Mol Sci. 2022 Jun 25;23(13):7092. doi: 10.3390/ijms23137092.
The high prevalence of metabolic syndrome in persons with schizophrenia has spurred investigational efforts to study the mechanism beneath its pathophysiology. Early psychosis dysfunction is present across multiple organ systems. On this account, schizophrenia may be a multisystem disorder in which one organ system is predominantly affected and where other organ systems are also concurrently involved. Growing evidence of the overlapping neurobiological profiles of metabolic risk factors and psychiatric symptoms, such as an association with cognitive dysfunction, altered autonomic nervous system regulation, desynchrony in the resting-state default mode network, and shared genetic liability, suggest that metabolic syndrome and schizophrenia are connected via common pathways that are central to schizophrenia pathogenesis, which may be underpinned by oxytocin system dysfunction. Oxytocin, a hormone that involves in the mechanisms of food intake and metabolic homeostasis, may partly explain this piece of the puzzle in the mechanism underlying this association. Given its prosocial and anorexigenic properties, oxytocin has been administered intranasally to investigate its therapeutic potential in schizophrenia and obesity. Although the pathophysiology and mechanisms of oxytocinergic dysfunction in metabolic syndrome and schizophrenia are both complex and it is still too early to draw a conclusion upon, oxytocinergic dysfunction may yield a new mechanistic insight into schizophrenia pathogenesis and treatment.
精神分裂症患者代谢综合征的高发率促使人们研究其病理生理学的机制。早期精神病功能障碍存在于多个器官系统中。因此，精神分裂症可能是一种多系统疾病，其中一个器官系统受到主要影响，其他器官系统也同时受到影响。越来越多的证据表明，代谢风险因素和精神症状的神经生物学特征存在重叠，例如与认知功能障碍、自主神经系统调节改变、静息状态默认模式网络去同步和共同的遗传易感性有关，这表明代谢综合征和精神分裂症通过与精神分裂症发病机制有关的共同途径联系在一起，这些途径可能是由催产素系统功能障碍所支撑。催产素是一种参与进食和代谢稳态机制的激素，可能部分解释了这种关联的机制。鉴于其亲社会和抑制食欲的特性，已经鼻内给予催产素以研究其在精神分裂症和肥胖症中的治疗潜力。尽管代谢综合征和精神分裂症中催产素能功能障碍的病理生理学和机制都很复杂，而且目前还为时过早，无法得出结论，但催产素能功能障碍可能为精神分裂症发病机制和治疗提供新的机制见解。
