Sessle B J, Henry J L
Brain Res. 1987 Mar 24;407(1):163-7. doi: 10.1016/0006-8993(87)91232-7.
In anaesthetized cats, effects of iontophoretic application of angiotensin II were studied in the nuclei of the tractus solitarius. Specifically, its effects were tested on single respiratory neurones, having rhythmic activity related temporally with the phrenic nerve discharge, and on presumed reflex interneurones, which lacked rhythmic activity but responded to stimulation of vagus nerve or superior laryngeal nerve. Angiotensin II (30-100 nA positive current for 30-60 s) excited 8/27 respiratory neurones; 19 were unaffected. Five of 8 reflex interneurones were excited; 3 were unaffected. Excitation consisted of a delayed, slow increase in the rate of firing which continued for about 60-120 s following the end of ejection. These results provide physiological evidence to support the possibility that angiotensin II may be a chemical mediator of synaptic transmission in the nuclei of the tractus solitarii, in pathways related to respiratory control.
在麻醉猫中，研究了血管紧张素II离子导入法应用于孤束核的效应。具体而言，测试了其对具有与膈神经放电在时间上相关的节律性活动的单个呼吸神经元，以及对缺乏节律性活动但对迷走神经或喉上神经刺激有反应的假定反射中间神经元的影响。血管紧张素II（30 - 100 nA正电流，持续30 - 60秒）使27个呼吸神经元中的8个兴奋；19个未受影响。8个反射中间神经元中有5个被兴奋；3个未受影响。兴奋表现为放电率延迟、缓慢增加，在喷射结束后持续约60 - 120秒。这些结果提供了生理学证据，支持血管紧张素II可能是与呼吸控制相关通路中孤束核突触传递的化学介质这一可能性。
