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逆向潜伏期跳跃是否表明黑质纹状体和下丘脑-神经垂体神经元存在轴突分支?

Do antidromic latency jumps indicate axonal branching in nigrostriatal and hypothalamo-neurohypophysial neurons?

作者信息

Klemfuss H, Young S J, Groves P M

出版信息

Brain Res. 1987 Apr 14;409(1):197-203. doi: 10.1016/0006-8993(87)90760-8.

DOI:10.1016/0006-8993(87)90760-8
PMID:3580868
Abstract

Neurons in many brain regions exhibit discontinuous decreases in antidromic latency with small increases in stimulating current. We used an electrophysiological test requiring a single stimulating electrode to determine whether these 'latency jumps' are due to shifts in the site of spike initiation to the same or different axon branches. Latency jumps in response to stimulation of the striatal terminal fields of substantia nigra, pars compacta neurons represent spike initiation on different branches while those seen in paraventricular neurons with pituitary stalk stimulation usually reflect a change in site on a single branch.

摘要

许多脑区的神经元在刺激电流小幅增加时,其逆向潜伏期会出现不连续的下降。我们采用一种需要单个刺激电极的电生理测试,以确定这些“潜伏期跳跃”是否是由于动作电位起始位点转移到相同或不同的轴突分支所致。对黑质致密部神经元的纹状体终末场进行刺激时出现的潜伏期跳跃代表在不同分支上的动作电位起始,而对室旁核神经元进行垂体柄刺激时出现的潜伏期跳跃通常反映单个分支上位点的变化。

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