Yamanaka K, Muramatsu I, Kigoshi S
Brain Res. 1987 Apr 21;409(2):395-7. doi: 10.1016/0006-8993(87)90730-x.
Carbamylcholine binding was determined from competition experiments with [3H] quinuclidinyl benzilate in the rat brain chronically treated with nicotine. The nicotine group exhibited about two-fold lower affinity for the agonist binding toward a high-affinity site (or state) in the cerebral cortex, as compared with the control group. However, no alteration in the agonist binding was observed in the hypothalamus/thalamus and brainstem after chronic nicotine treatment.
通过用[3H] 喹核醇基苯甲酸酯在长期给予尼古丁的大鼠脑中进行竞争实验来测定氨甲酰胆碱结合。与对照组相比，尼古丁组对大脑皮层中高亲和力位点（或状态）的激动剂结合的亲和力降低了约两倍。然而，长期给予尼古丁后，下丘脑/丘脑和脑干中的激动剂结合未观察到改变。
