School of Psychology, Shaanxi Normal University, and Key Laboratory for Behavior and Cognitive Neuroscience of Shaanxi Province, Xi'an, China.
Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA, University of Bordeaux, Bordeaux, France.
Hum Brain Mapp. 2022 Dec 1;43(17):5210-5219. doi: 10.1002/hbm.25997. Epub 2022 Jul 9.
It has been suggested that developmental dyslexia may have two dissociable causes-a phonological deficit and a visual attention span (VAS) deficit. Yet, neural evidence for such a dissociation is still lacking. This study adopted a data-driven approach to white matter network analysis to explore hubs and hub-related networks corresponding to VAS and phonological accuracy in a group of French dyslexic children aged from 9 to 14 years. A double dissociation in brain-behavior relations was observed. Structural connectivity of the occipital-parietal network surrounding the left superior occipital gyrus hub accounted for individual differences in dyslexic children's VAS, but not in phonological processing accuracy. In contrast, structural connectivity of two networks: the temporal-parietal-occipital network surrounding the left middle temporal gyrus hub and the frontal network surrounding the left medial orbital superior frontal gyrus hub, accounted for individual differences in dyslexic children's phonological processing accuracy, but not in VAS. Our findings provide evidence in favor of distinct neural circuits corresponding to VAS and phonological deficits in developmental dyslexia. The study points to connectivity-constrained white matter subnetwork dysfunction as a key principle for understanding individual differences of cognitive deficits in developmental dyslexia.
有人提出，发展性阅读障碍可能有两个可分离的原因——语音缺陷和视觉注意力跨度（VAS）缺陷。然而，这种分离的神经证据仍然缺乏。本研究采用数据驱动的方法对白质网络分析，以探索在一组年龄在 9 至 14 岁的法国阅读障碍儿童中，与 VAS 和语音准确性相对应的大脑网络的节点和节点相关网络。观察到脑-行为关系的双重分离。左侧顶枕叶网络的结构连接性，以左侧上顶叶节点为中心，解释了阅读障碍儿童 VAS 的个体差异，但不能解释语音处理准确性的个体差异。相比之下，两个网络的结构连接性——以左侧中颞叶节点为中心的颞顶枕叶网络和以左侧内侧眶额上额回节点为中心的额网络——解释了阅读障碍儿童语音处理准确性的个体差异，但不能解释 VAS。我们的研究结果为发展性阅读障碍中 VAS 和语音缺陷对应的不同神经回路提供了证据。该研究指出，连接受限的白质子网络功能障碍是理解发展性阅读障碍中认知缺陷个体差异的关键原则。
