Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
J Clin Lab Anal. 2022 Aug;36(8):e24597. doi: 10.1002/jcla.24597. Epub 2022 Jul 9.
The purpose of this study was to explore the clinical significance of serum ferritin (SF) in patients with systemic sclerosis (SSc).
The levels of SF were measured in 115 patients with SSc and 117 healthy controls (HCs). Clinical characteristics and laboratory indexes between the high ferritin SSc group and the normal ferritin SSc group were analyzed.
The level of SF in SSc patients was significantly higher than that in HCs (319.78 [179, 554.33] ng/ml vs. 99 [49.03, 164.29] ng/ml, p < 0.01). Compared with the normal ferritin SSc group, the high ferritin SSc group was more likely to develop skin diffuse cutaneous SSc, fingertip arthralgia, and cardiac involvement. In addition, the levels of glutamine transaminase (GGT), alanine aminotransferase (ALT), creatine kinase (CK), creatine kinase isoenzyme-MB (CK-MB), lactate dehydrogenase (LD), immunoglobulin G (IgG), immunoglobulin A (IgA), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and the positive rate of anti-Scl70 antibody in the high ferritin SSc group were significantly higher (each p < 0.05). SF was positively correlated with GGT, ALT, CK, CK-MB, LD, IgA, CRP, and ESR (each p < 0.05). Multiple linear regression analysis showed that cardiac involvement, ALT, and ESR were independent influencing factors of SF in SSc.
Our study shows that the level of SF in patients with SSc is increased, and the elevated SF is related to abnormal liver function, myocardial involvement, inflammatory status, and production of autoantibodies in SSc. Cardiac involvement, ALT, and ESR are independent factors affecting SF in SSc.
本研究旨在探讨血清铁蛋白（SF）在系统性硬化症（SSc）患者中的临床意义。
检测 115 例 SSc 患者和 117 例健康对照者（HCs）的 SF 水平，分析高铁蛋白 SSc 组与正常铁蛋白 SSc 组之间的临床特征和实验室指标。
SSc 患者 SF 水平明显高于 HCs（319.78[179,554.33]ng/ml 比 99[49.03,164.29]ng/ml，p<0.01）。与正常铁蛋白 SSc 组相比，高铁蛋白 SSc 组更易发生弥漫性皮肤型 SSc、指尖关节炎和心脏受累。此外，高铁蛋白 SSc 组的谷氨酰转肽酶（GGT）、丙氨酸氨基转移酶（ALT）、肌酸激酶（CK）、肌酸激酶同工酶-MB（CK-MB）、乳酸脱氢酶（LD）、免疫球蛋白 G（IgG）、免疫球蛋白 A（IgA）、C 反应蛋白（CRP）、红细胞沉降率（ESR）和抗 Scl70 抗体阳性率均明显升高（均 p<0.05）。SF 与 GGT、ALT、CK、CK-MB、LD、IgA、CRP 和 ESR 呈正相关（均 p<0.05）。多元线性回归分析显示，心脏受累、ALT 和 ESR 是 SSc 患者 SF 的独立影响因素。
本研究表明 SSc 患者 SF 水平升高，升高的 SF 与 SSc 患者肝功能异常、心肌受累、炎症状态和自身抗体产生有关。心脏受累、ALT 和 ESR 是影响 SSc 患者 SF 的独立因素。
