将全面肿瘤基因组分析结果返回给晚期癌症患者：一项定性研究。
Return of comprehensive tumour genomic profiling results to advanced cancer patients: a qualitative study.
机构信息
Institute for Ethics and Society, University of Notre Dame Australia, Sydney, NSW, Australia.
Psycho-Oncology Co-Operative Research Group (PoCoG), University of Sydney, Sydney, NSW, Australia.
出版信息
Support Care Cancer. 2022 Oct;30(10):8201-8210. doi: 10.1007/s00520-022-07272-3. Epub 2022 Jul 9.
PURPOSE
The introduction of comprehensive tumour genomic profiling (CGP) into clinical oncology allows the identification of molecular therapeutic targets. However, the potential complexity of genomic results and their implications may cause confusion and distress for patients undergoing CGP. We investigated the experience of advanced cancer patients receiving CGP results in a research setting.
METHODS
Semi-structured interviews with 37 advanced cancer patients were conducted within two weeks of patients receiving CGP results. Interviewees were purposively sampled based on CGP result, cancer type, age and gender to ensure diversity. Themes were derived from interview transcripts using a framework analysis approach.
RESULTS
We identified six themes: (1) hoping against the odds; (2) managing expectations; (3) understanding is cursory; (4) communication of results is cursory; (5) genomics and incurable cancer; and (6) decisions about treatment.
CONCLUSION
Despite enthusiasm regarding CGP about the hope it provides for new treatments, participants experienced challenges in understanding results, and acceptance of identified treatments was not automatic. Support is needed for patients undergoing CGP to understand the implications of testing and cope with non-actionable results.
目的
综合肿瘤基因组分析（CGP）引入临床肿瘤学可识别分子治疗靶点。然而，基因组结果的潜在复杂性及其影响可能会导致接受 CGP 的患者感到困惑和苦恼。我们在研究环境中调查了接受 CGP 结果的晚期癌症患者的体验。
方法
在患者接受 CGP 结果后的两周内，对 37 名晚期癌症患者进行了半结构化访谈。根据 CGP 结果、癌症类型、年龄和性别对受访者进行了有针对性的抽样，以确保多样性。使用框架分析方法从访谈记录中提取主题。
结果
我们确定了六个主题：（1）希望渺茫；（2）管理期望；（3）理解肤浅；（4）结果沟通肤浅；（5）基因组学与不可治愈的癌症；（6）治疗决策。
结论
尽管对 CGP 抱有新治疗方法带来希望的热情，但参与者在理解结果方面遇到了挑战，对确定的治疗方法的接受并非自动。需要为接受 CGP 的患者提供支持，以了解测试的含义并应对无法采取行动的结果。
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