Foot and Ankle Surgery Center, Beijing Tongren Hospital of Capital Medical University, Beijing 100005, China.
Cell Mol Biol (Noisy-le-grand). 2022 May 22;68(1):140-146. doi: 10.14715/cmb/2022.68.1.18.
MicroRNAs (miRNAs) have been documented to function differently in numerous human cancers. Our study planned to investigate the role of microRNA-140 (miR-140) and to identify its possible target in osteosarcoma (OS) to predict their mechanism in OS. The miR-140 was down-regulated in OS, and its high expression decreased MG63 cell proliferation. At the molecular level, Wnt1 was a target of miR-140, and its expression could be suppressed by miR-140. Besides, miR-140 overexpression decreased drug resistance in OS cells treated by doxorubicin. Collectively, overexpression of miR-140 may inhibit human OS cell proliferation and may enhance drug sensitivity by direct regulation of Wnt/β-catenin signaling.
微小 RNA（miRNAs）在许多人类癌症中发挥着不同的功能。我们的研究计划探讨 microRNA-140（miR-140）的作用，并确定其在骨肉瘤（OS）中的可能靶点，以预测其在 OS 中的机制。miR-140 在 OS 中下调，其高表达可降低 MG63 细胞的增殖。在分子水平上，Wnt1 是 miR-140 的靶标，其表达可被 miR-140 抑制。此外，miR-140 的过表达可降低阿霉素处理的 OS 细胞的耐药性。总之，miR-140 的过表达可能通过直接调节 Wnt/β-catenin 信号通路抑制人骨肉瘤细胞的增殖，并增强药物敏感性。
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