Aikawa N, Shinozawa Y, Ishibiki K, Abe O, Yamamoto S, Motegi M, Yoshii H, Sudoh M
Burns Incl Therm Inj. 1987 Apr;13(2):103-9. doi: 10.1016/0305-4179(87)90097-0.
Severely burned patients often show various degrees of organ failures, and when several vital organs are involved mortality becomes extremely high. A study was undertaken to elucidate the aetiology and clinical significance of multiple organ failure (MOF) in burned patients. One hundred and fifty-eight burned patients were analysed for organ failures in five vital organs or systems, the heart, lung, liver, kidney and blood clotting system. There were 91 organ failures observed in 34 patients, of which 26 had MOF. The most frequently affected organ was the lung, followed by the heart, kidney, liver and the blood clotting system. The mortality rate was 76.9 per cent in MOF and 1.5 per cent in non-MOF patients. Septicaemia was closely associated with the development of MOF. Also, inhalation injury and 'shock' were contributing factors to the morbidity. Five extensively burned patients had an early development of MOF without infectious foci and this type of early MOF was attributed to endotoxaemia possibly originating from the patient's own intestinal flora.
严重烧伤患者常出现不同程度的器官衰竭，若多个重要器官受累，死亡率会极高。开展了一项研究以阐明烧伤患者多器官功能衰竭（MOF）的病因及临床意义。对158例烧伤患者的五个重要器官或系统（心脏、肺、肝、肾及凝血系统）的器官功能衰竭情况进行了分析。34例患者出现了91次器官功能衰竭，其中26例发生了MOF。最常受累的器官是肺，其次是心脏、肾、肝及凝血系统。MOF患者的死亡率为76.9%，非MOF患者的死亡率为1.5%。败血症与MOF的发生密切相关。此外，吸入性损伤和“休克”是发病的促成因素。五例大面积烧伤患者早期出现了MOF且无感染灶，这种早期MOF可能归因于内毒素血症，其可能源于患者自身的肠道菌群。
