Department of Orthopedic Surgery, Loma Linda University Medical Center, Loma Linda, CA, USA.
Loma Linda University School of Medicine, Loma Linda, CA, USA.
J Clin Neurosci. 2022 Sep;103:41-43. doi: 10.1016/j.jocn.2022.06.030. Epub 2022 Jul 6.
Patients with Adolescent Idiopathic Scoliosis (AIS) have increased prevalence of lower bone mineral density (BMD) compared to healthy adolescents. Our goal was to compare bone density in patients with AIS and a nonaffected control group using an MRI-based vertebral bone quality (VBQ) score. We reviewed 50 consecutive lumbar MRIs of patients with AIS and of 50 nonaffected controls that were matched for age and sex. The VBQ score was calculated and compared between the groups. The VBQ score for the AIS group was 2.5 (SD 0.4) and for the control group 2.1 (SD 0.3) (p < 0.001). Multiple linear regression analyses were performed for control of confounding from body weight, body height, corrected BMI, and Cobb angle. Besides the diagnosis of AIS, there was no variable that was independently associated with the VBQ score. This is the first study to evaluate bone density in pediatric patients with AIS. We found a significant difference in the VBQ-score between patients with AIS and nonaffected controls matched for sex, age, and race. MRI can be used to assess the bone quality in patients with adolescent idiopathic scoliosis.
青少年特发性脊柱侧凸（AIS）患者的骨密度（BMD）比健康青少年更高。我们的目标是使用基于 MRI 的椎体骨质量（VBQ）评分比较 AIS 患者和无影响对照组的骨密度。我们回顾了 50 例连续的 AIS 患者和 50 例年龄和性别匹配的无影响对照组的腰椎 MRI。计算并比较了两组的 VBQ 评分。AIS 组的 VBQ 评分为 2.5（SD 0.4），对照组为 2.1（SD 0.3）（p<0.001）。为了控制体重、身高、校正 BMI 和 Cobb 角等混杂因素的影响，我们进行了多变量线性回归分析。除了 AIS 的诊断外，没有其他变量与 VBQ 评分独立相关。这是第一项评估青少年特发性脊柱侧凸患儿骨密度的研究。我们发现 AIS 患者与性别、年龄和种族匹配的无影响对照组之间的 VBQ 评分存在显著差异。MRI 可用于评估青少年特发性脊柱侧凸患者的骨质量。
