INSERM, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat, 33077 Bordeaux, France; Univ. Bordeaux, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat, 33077 Bordeaux, France.
Curr Opin Neurobiol. 2022 Oct;76:102600. doi: 10.1016/j.conb.2022.102600. Epub 2022 Jul 6.
Our understanding of the neuronal circuits and mechanisms of defensive systems has been primarily dominated by studies focusing on the contribution of individual cells in the processing of threat-predictive cues, defensive responses, the extinction of such responses and the contextual modulation of threat-related behavior. These studies have been key in establishing threat-related circuits and mechanisms. Yet, they fall short in answering long-standing questions related to the integrative processing of distinct threatening cues, behavioral states induced by threat-related events, or the bridging from sensory processing of threat-related cues to specific defensive responses. Recent conceptual and technical developments has allowed the monitoring of large populations of neurons, which in addition to advanced analytic tools, have improved our understanding of how collective neuronal activity supports threat-related behaviors. In this review, we discuss the current knowledge of neuronal population codes within threat-related networks, in the context of aversive motivated behavior and the study of defensive systems.
我们对防御系统的神经元回路和机制的理解主要是基于研究个别细胞在处理威胁预测线索、防御反应、此类反应的消除以及与威胁相关的行为的上下文调节方面的贡献。这些研究对于确定与威胁相关的回路和机制是至关重要的。然而，它们在回答与以下方面相关的长期问题方面存在不足：不同威胁线索的综合处理、与威胁相关的事件引起的行为状态，或者从与威胁相关的线索的感觉处理到特定防御反应的过渡。最近的概念和技术发展允许对大量神经元进行监测，除了先进的分析工具外，这还提高了我们对集体神经元活动如何支持与威胁相关的行为的理解。在这篇综述中，我们讨论了在厌恶动机行为和防御系统的研究背景下，与威胁相关的网络中神经元群体编码的现有知识。
