Regional Center for Pediatric Diabetes, Department of Pediatrics, University of the Study of Campania, via Sant'Andrea delle Dame,4, Naples, 80138, Italy.
Regional Center for Pediatric Diabetes, Department of Pediatrics, University of the Study of Campania, via Sant'Andrea delle Dame,4, Naples, 80138, Italy.
Diabetes Metab Syndr. 2022 Jul;16(7):102561. doi: 10.1016/j.dsx.2022.102561. Epub 2022 Jun 30.
When very low doses of insulin are used insulin dilution, a procedure prone to errors, is recommended.
We managed a neonate with pancreas agenesis with insulin pump therapy from the first days of life to 16 months of age without insulin dilution. Predictive low glucose suspend mode first and then closed loop control were used. No episodes of severe hypoglycemia were observed.
Though limited to a single patient with pancreas agenesis we believe that the use of pump should be warranted in patients with permanent neonatal diabetes mellitus and intestinal malabsorption, even with undiluted insulin.
当使用极低剂量胰岛素时，建议进行胰岛素稀释，这是一种容易出错的操作。
我们对一名患有胰腺发育不全的新生儿从出生第一天开始使用胰岛素泵治疗，直到 16 个月大，没有进行胰岛素稀释。我们使用了预测性低血糖暂停模式，然后是闭环控制。没有观察到严重低血糖发作的情况。
虽然仅限于一名胰腺发育不全的患者，但我们认为即使胰岛素没有稀释，对于永久性新生儿糖尿病和肠道吸收不良的患者，也应该使用胰岛素泵进行治疗。
