Ministry of Education (MOE) Key Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China; Department of Hepatobiliary and Pancreatic Surgery and Zhejiang Provincial Key Laboratory of Pancreatic Disease, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Trends Biochem Sci. 2022 Dec;47(12):1059-1072. doi: 10.1016/j.tibs.2022.06.001. Epub 2022 Jul 6.
The transforming growth factor β (TGF-β) superfamily controls a wide spectrum of biological processes in metazoans, including cell proliferation, apoptosis, differentiation, cell-fate determination, and embryonic development. Deregulation of TGF-β-Smad signaling contributes to developmental anomalies and a variety of disorders and diseases such as tumorigenesis, fibrotic disorders, and immune diseases. In cancer, TGF-β has dual effects through its antiproliferative and prometastatic actions. At the cellular level, TGF-β functions mainly through the canonical Smad-dependent pathway in a cell type-specific and context-dependent manner. Accumulating evidence has demonstrated that ubiquitination plays a vital role in regulating TGF-β-Smad signaling. We summarize current progress on ubiquitination (Ub) and the ubiquitin ligases that regulate TGF-β-Smad signaling.
转化生长因子β (TGF-β) 超家族在后生动物中控制着广泛的生物学过程，包括细胞增殖、凋亡、分化、细胞命运决定和胚胎发育。TGF-β-Smad 信号转导的失调导致了发育异常以及多种疾病和病症，如肿瘤发生、纤维化疾病和自身免疫性疾病。在癌症中，TGF-β 通过其抗增殖和促转移作用具有双重作用。在细胞水平上，TGF-β 主要通过细胞类型特异性和上下文依赖性的经典 Smad 依赖性途径发挥作用。越来越多的证据表明，泛素化在调节 TGF-β-Smad 信号转导中起着至关重要的作用。我们总结了泛素化 (Ub) 和调节 TGF-β-Smad 信号转导的泛素连接酶的最新进展。
