HIV 感染与心力衰竭风险：荟萃分析和系统评价。

HIV infection and risk of heart failure: A meta-analysis and systematic review.

机构信息

Department of infectious diseases, YiWu Central Hospital, Zhejiang 322000, China.

出版信息

Acta Biochim Pol. 2022 Jul 10;69(3):531-535. doi: 10.18388/abp.2020_5718.

DOI:10.18388/abp.2020_5718

PMID:35810484

Abstract

BACKGROUND

Heart failure (HF) is commonly seen in patients with human immunodeficiency virus (HIV) infection. We aimed to evaluate the potential correlations of HIV infection and risk of HF, to provide evidence to the management of HIV and HF.

METHODS

We searched PubMed and other databases to identify prospective cohort studies on the risk of HIV infection and heart failure, we used Stata 13 software for Meta-analysis, and we calculated the hazard ratio (HR) values and 95% confidence interval (CI) values for the risks of HF in patients with and without HIV infections.

RESULTS

A total of five studies were included, with 8457 cases in the HIV-infection and 21917 cases in the non-HIV-infection group. Meta-analysis results showed that HIV infection can increase the risk of HF by 48% (HR=1.48, 95% CI1.31~1.67). Subgroups analyses by HIV-1 RNA viral load, CD4+ cell count, and study population also favored the overall results, and the research heterogeneity mainly come from the group of veterans in the research population.

CONCLUSIONS

HIV infection is one of the risk factors for HF, which can increase the risk of heart failure, early preventions and interventions are needed for those populations.

摘要

背景

心力衰竭（HF）在人类免疫缺陷病毒（HIV）感染患者中较为常见。我们旨在评估 HIV 感染与 HF 风险的潜在相关性，为 HIV 和 HF 的管理提供依据。

方法

我们检索了 PubMed 和其他数据库，以确定关于 HIV 感染和心力衰竭风险的前瞻性队列研究，我们使用 Stata 13 软件进行 Meta 分析，并计算了 HIV 感染和非 HIV 感染患者 HF 风险的危害比（HR）值和 95%置信区间（CI）值。

结果

共纳入了 5 项研究，其中 HIV 感染组有 8457 例，非 HIV 感染组有 21917 例。Meta 分析结果表明，HIV 感染可使 HF 的风险增加 48%（HR=1.48，95%CI1.31~1.67）。按 HIV-1 RNA 病毒载量、CD4+细胞计数和研究人群进行亚组分析也支持总体结果，研究异质性主要来自研究人群中的退伍军人组。