Department of Dermatology, Chengdu University of Traditional Chinese Medicine Affiliated Hospital, No.39 Shi-er-Qiao Road, Chengdu 610072, Sichuan Province, PR China.
Int Immunopharmacol. 2022 Sep;110:109032. doi: 10.1016/j.intimp.2022.109032. Epub 2022 Jul 8.
Psoriasis is an incurable, chronic inflammatory disease, which brings a substantial burden on individuals and society. Currently, the treatment of psoriasis has entered the era of biologics, but its highly targeting of inflammatory mediators may enable the immune response to circumvent the blockade, leading to disease recurrence, or other clinical and immunological characteristics. Therefore, the discovery of new therapies that have the ability of multidirectional regulation on immunity and maintain the dynamic balance of immunity in psoriasis, may be the key to the treatment of the disease. Natural products extracted from herbal medicines have synergistic effects to alleviate psoriasis and its comorbidities because of their structural diversity and multiple active mechanisms. To date, the characteristics of natural products regulating T helper 17 (Th17) cells/regulatory T (Treg) cells balance in the treatment of psoriasis have attracted more and more attention from basic and clinical studies. In this review, we systematically introduced the natural products regulating the balance of Th17/Treg and their specific mechanism of action, finding Datura metel L, Grape seed proanthocyanidin extract (GSPE), Thymol, Kaempferol, Aloperine, Abietic acid (AA), Isogarcinol, Luteolin reduced the frequency and function of Th17 cells and simultaneously increased that of Treg cells. It is expected that our work can provide a reference for clinicians in drug use.
银屑病是一种无法治愈的慢性炎症性疾病，给个人和社会带来了沉重的负担。目前，银屑病的治疗已经进入生物制剂时代，但它对炎症介质的高度靶向性可能使免疫反应绕过阻断，导致疾病复发或出现其他临床和免疫特征。因此，发现能够对免疫进行多向调节并维持银屑病免疫动态平衡的新型治疗方法，可能是治疗该病的关键。从草药中提取的天然产物因其结构多样性和多种活性机制而具有协同缓解银屑病及其合并症的作用。迄今为止，天然产物调节辅助性 T 细胞 17（Th17）/调节性 T（Treg）细胞平衡治疗银屑病的特点，越来越受到基础和临床研究的关注。在这篇综述中，我们系统地介绍了调节 Th17/Treg 平衡的天然产物及其具体作用机制，发现曼陀罗、葡萄籽原花青素提取物（GSPE）、百里香酚、山奈酚、阿朴啡碱、松香酸（AA）、异桉脂醇、木樨草素可降低 Th17 细胞的频率和功能，同时增加 Treg 细胞的频率和功能。我们希望我们的工作能为临床医生的用药提供参考。
