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脂肪营养不良女性吸脂术后淋巴管损伤的病例系列

A Case Series of Lymphatic Injuries After Suction Lipectomy in Women with Lipedema.

机构信息

Suregry, Lipedema Surgical Solutions, St. Louis, MO, USA.

Director of Research, Total Lipedema Care, Beverly Hills, CA, USA.

出版信息

Am J Case Rep. 2022 Jul 11;23:e935016. doi: 10.12659/AJCR.935016.

DOI:10.12659/AJCR.935016
PMID:35811389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9284075/
Abstract

BACKGROUND Lipedema is a loose connective tissue disease characterized by disproportionate subcutaneous adipose tissue hypertrophy in the extremities. There is evidence of impaired lymphatic function in women with lipedema at all stages without signs of trophic skin changes associated with hereditary or acquired lymphedema. A modification of suction lipectomy is used to treat lipedema tissue and can reduce pain, limb size, and limb swelling and reduce the need for compression in women with lipedema. Studies have shown that modified liposuction can improve quality of life and mobility. There are no reports of lymphatic injury after suction lipectomy in patients with lipedema in PubMed indexed journals. CASE REPORT Three women with lipedema who had no prior venous or lymphatic disease developed new-onset symptomatic International Society of Lymphology (ISL) Stage 2 or 3 lymphedema and skin and tissue changes within 6 months to 1 year after suction lipectomy for lipedema tissue on the legs. Each of the 3 women had their surgeries performed using different suction devices and under different types of anesthesia. Two of the lymphatic injury cases had subsequent nuclear lymphoscintigrams that confirmed impaired lymphatic function. CONCLUSIONS We report 3 cases of women with lymphatic injuries after modified suction lipectomy to treat lipedema. Clinical history, exams, and confirmatory studies support the assessment that suction lipectomy caused newly-manifested signs and symptoms of lymphedema. Further study is needed to determine the risk of permanent lymphatic injury with suction lipectomy in larger numbers of lipedema patients.

摘要

背景

脂肪营养不良是一种疏松结缔组织疾病,其特征为肢体皮下脂肪组织不成比例地肥大。有证据表明,脂肪营养不良患者在所有阶段的淋巴功能都受损,而没有与遗传性或获得性淋巴水肿相关的营养性皮肤改变的迹象。改良吸脂术用于治疗脂肪营养不良组织,可以减轻疼痛、肢体大小和肢体肿胀,并减少脂肪营养不良妇女对压缩的需求。研究表明,改良吸脂术可以提高生活质量和活动能力。在 PubMed 索引期刊中,没有关于脂肪抽吸术后脂肪营养不良患者发生淋巴损伤的报道。

病例报告

3 名女性脂肪营养不良患者,无先前静脉或淋巴疾病,在腿部脂肪抽吸术治疗脂肪营养不良组织后 6 个月至 1 年内出现新发性国际淋巴学会(ISL)2 期或 3 期淋巴水肿和皮肤及组织变化。这 3 名女性中的每一位都使用不同的吸脂设备和不同类型的麻醉进行了手术。2 例淋巴损伤病例随后进行了核淋巴闪烁成像检查,证实了淋巴功能受损。

结论

我们报告了 3 例女性改良吸脂术后发生淋巴损伤的病例。临床病史、检查和确认性研究支持评估认为吸脂术导致新出现的淋巴水肿的体征和症状。需要进一步研究以确定在更多脂肪营养不良患者中吸脂术引起永久性淋巴损伤的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79c/9284075/e3da7fa6819e/amjcaserep-23-e935016-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79c/9284075/3d0a4248c6ad/amjcaserep-23-e935016-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79c/9284075/a898d519fc9a/amjcaserep-23-e935016-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79c/9284075/e42317dfa9cf/amjcaserep-23-e935016-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79c/9284075/dfb57e8fa4ad/amjcaserep-23-e935016-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79c/9284075/e7a39c845475/amjcaserep-23-e935016-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79c/9284075/e3da7fa6819e/amjcaserep-23-e935016-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79c/9284075/3d0a4248c6ad/amjcaserep-23-e935016-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79c/9284075/a898d519fc9a/amjcaserep-23-e935016-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79c/9284075/e42317dfa9cf/amjcaserep-23-e935016-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79c/9284075/dfb57e8fa4ad/amjcaserep-23-e935016-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79c/9284075/e7a39c845475/amjcaserep-23-e935016-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d79c/9284075/e3da7fa6819e/amjcaserep-23-e935016-g006.jpg

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Adipose Tissue Hypertrophy, An Aberrant Biochemical Profile and Distinct Gene Expression in Lipedema.脂肪组织肥大,脂肪水肿的异常生化特征和独特基因表达。
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