Wong Jolene Si Min, Tan Grace Hwei Ching, Cheok Sabrina Hui Xian, Ong Chin-Ann Johnny, Chia Claramae Shulyn, Teo Melissa Ching Ching
Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Division of Surgery and Surgical Oncology, Singapore General Hospital, Singapore, Singapore.
Pleura Peritoneum. 2022 Apr 26;7(2):95-102. doi: 10.1515/pp-2021-0150. eCollection 2022 Jun 1.
Peritoneal cancer index (PCI) score is a common prognostication tool in peritoneal metastases (PM). We hypothesize that the distribution of PCI score and involvement of specific regions affects survival and morbidity outcomes.
Data was collected from a prospective database of patients who underwent CRS and HIPEC for PM at the National Cancer Centre Singapore. We evaluate the relationship between PCI, PCI distribution, and survival and morbidity outcomes.
One hundred and fifty-two patients underwent CRS and HIPEC with a median PCI score of nine (range 0-31). Median overall survival (OS) and progression free survival (PFS) were 43 and 17 months, respectively. Region six (pelvis) was most commonly involved and had the highest frequency of heavy disease burden. Presence of PM in the lower abdomen, flanks, and small bowel were associated with poorer OS (p=0.01, 0.03, <0.001) and PFS (p=0.04, 0.02, <0.001). Involvement of porta hepatitis predicted poorer OS but not PFS (p=0.03). Involvement of the gastric antrum resulted in higher rates of postoperative complications.
The pattern of PCI distribution may be associated with varying survival and morbidity outcomes.
腹膜癌指数（PCI）评分是腹膜转移（PM）中常用的预后评估工具。我们假设PCI评分的分布及特定区域的受累情况会影响生存和发病结局。
数据收集自新加坡国立癌症中心接受CRS和HIPEC治疗PM患者的前瞻性数据库。我们评估PCI、PCI分布与生存和发病结局之间的关系。
152例患者接受了CRS和HIPEC治疗，PCI评分中位数为9（范围0 - 31）。总生存（OS）和无进展生存（PFS）的中位数分别为43个月和17个月。区域六（骨盆）最常受累，且疾病负担重的频率最高。下腹部、侧腹和小肠存在PM与较差的OS（p = 0.01、0.03、<0.001）和PFS（p = 0.04、0.02、<0.001）相关。肝门受累预示较差的OS，但不影响PFS（p = 0.03）。胃窦受累导致术后并发症发生率更高。
PCI分布模式可能与不同的生存和发病结局相关。
