Maliha Maisha, Roksana Zinath, Babli Shimul A, Chowdhury Khaza, West David
Internal Medicine, Dhaka Medical College, Dhaka, BGD.
Internal Medicine, Feni Sadar Hospital, Feni, BGD.
Cureus. 2022 Jun 9;14(6):e25792. doi: 10.7759/cureus.25792. eCollection 2022 Jun.
Pachymeningitis is a rare disorder that involves the dura mater of the cranial and spinal nerves. It can lead to localized or diffuse thickening of the dura mater as an inflammatory reaction. Very little is known about this uncommon disease, and even less is known about its exacerbating factors and relationship with chemotherapy. In this report, we present a case of an 86-year-old man with metastatic bladder carcinoma on chemotherapy who experienced worsening pachymeningitis with symptoms such as headache, aphasia, weakness, and seizures. The patient responded well to steroids, and his symptoms improved. This association between exacerbation of pachymeningitis and chemotherapy is rarely encountered, and its mechanism of action is poorly understood. We hope this case report will add to the existing literature on this uncommon phenomenon and its exacerbating factors.
硬脑膜炎是一种罕见的疾病，累及颅神经和脊神经的硬脑膜。作为一种炎症反应，它可导致硬脑膜局部或弥漫性增厚。对于这种罕见疾病，人们了解甚少，对其加重因素以及与化疗的关系更是知之甚少。在本报告中，我们呈现了一例86岁患有转移性膀胱癌且正在接受化疗的男性病例，该患者硬脑膜炎病情恶化，出现了头痛、失语、虚弱和癫痫发作等症状。患者对类固醇治疗反应良好，症状有所改善。硬脑膜炎加重与化疗之间的这种关联很少见，其作用机制也 poorly understood。我们希望本病例报告能为关于这一罕见现象及其加重因素的现有文献增添内容。 （注：原文中“poorly understood”直译为“理解不充分”，在中文语境下稍显生硬，可灵活调整表述方式，但题目要求不添加其他任何解释或说明，所以此处保留英文。）
