一例暴发性心肌炎尸检病例报告：接种新型冠状病毒mRNA疫苗后
An autopsy case report of fulminant myocarditis: Following mRNA COVID-19 vaccination.
作者信息
Hoshino Naoki, Yanase Masanobu, Ichiyasu Taisuke, Kuwahara Kazuhiko, Kawai Hideki, Muramatsu Takashi, Ishii Hideki, Tsukamoto Tetsuya, Morimoto Shin-Ichiro, Izawa Hideo
机构信息
Department of Cardiology, Fujita Health University School of Medicine, Toyoake, Japan.
Department of Diagnostic Pathology, Fujita Health University School of Medicine, Toyoake, Japan.
出版信息
J Cardiol Cases. 2022 Dec;26(6):391-394. doi: 10.1016/j.jccase.2022.06.006. Epub 2022 Jul 4.
UNLABELLED
There have been few case reports on fatal outcomes in patients with acute myocarditis after mRNA coronavirus disease 2019 (COVID-19) vaccination. In most cases of myocarditis after mRNA COVID-19 vaccination, the myocarditis is mild, and the prognosis is good. Here we report an autopsy case of fulminant myocarditis following mRNA COVID-19 vaccination.
LEARNING OBJECTIVE
The global distribution of the mRNA coronavirus disease 2019 vaccine requires consideration of appropriate treatment for postvaccination myocarditis. Eosinophil-mediated immunological injury to cardiomyocytes can be involved in the cause of fulminant inflammation from the pathological findings of postvaccination myocarditis.
未标注
关于2019冠状病毒病（COVID-19）mRNA疫苗接种后急性心肌炎患者出现致命结局的病例报告很少。在大多数mRNA COVID-19疫苗接种后心肌炎病例中，心肌炎症状较轻，预后良好。在此，我们报告1例mRNA COVID-19疫苗接种后暴发性心肌炎的尸检病例。
学习目标
2019冠状病毒病mRNA疫苗的全球分发需要考虑针对接种后心肌炎的适当治疗方法。从接种后心肌炎的病理结果来看，嗜酸性粒细胞介导的对心肌细胞的免疫损伤可能参与了暴发性炎症的病因。
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