Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan.
Int J Med Sci. 2022 May 29;19(6):1013-1022. doi: 10.7150/ijms.72378. eCollection 2022.
Single nucleotide polymorphisms (SNPs) of tissue inhibitor of metalloproteinases-3 () have been revealed to be related to various cancers. To date, no study explores the relationships between polymorphisms and uterine cervical cancer The purposes of this research were to investigate the associations among genetic variants of and development and clinicopathological factors of uterine cervical cancer, and patient 5 years survival in Taiwanese women. The study included 123 patients with invasive cancer and 97 with precancerous lesions of uterine cervix, and 300 control women. polymorphisms rs9619311, rs9862 and rs11547635 were checked and their genotypic distributions were determined by real-time polymerase chain reaction. It showed that women with genotypes CT/TT in rs9862 were found to display a higher risk of developing cervical cancer with moderate and poor cell differentiation. Moreover, it revealed that cervical cancer patients carrying genotypes CC in rs9619311 exhibited a poorer 5 years survival, as compared to those with TT/TC in Taiwanese women, using univariate analysis. In addition, pelvic lymph node metastasis was determined to independently predict 5 years survival in cervical cancer patients using multivariate analysis. Conclusively, SNPs polymorphisms rs9619311 are related to cervical patient survival in Taiwanese women.
单核苷酸多态性（SNPs）组织金属蛋白酶抑制剂-3（TIMP-3）已被揭示与各种癌症有关。迄今为止，尚无研究探讨 TIMP-3 多态性与子宫颈癌之间的关系。本研究旨在探讨遗传变异与子宫颈癌发展和临床病理因素的关系，并探讨台湾妇女患者 5 年生存率。该研究包括 123 例浸润性癌患者和 97 例宫颈癌前病变患者，以及 300 名对照女性。通过实时聚合酶链反应检测了 rs9619311、rs9862 和 rs11547635 的多态性，并确定了其基因型分布。结果表明，rs9862 中 CT/TT 基因型的女性发生中、低分化宫颈癌的风险较高。此外，单因素分析显示，与 TT/TC 基因型相比，rs9619311 中 CC 基因型的宫颈癌患者 5 年生存率较差。此外，多因素分析显示盆腔淋巴结转移可独立预测宫颈癌患者的 5 年生存率。总之，TIMP-3 SNPs 多态性 rs9619311 与台湾妇女宫颈癌患者的生存有关。
