Anggraini Neni, Mahyuddin Mutmainah, Siregar Nurjati Chairani
Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia.
Department of Anatomical Pathology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia.
Taiwan J Ophthalmol. 2021 Feb 12;12(2):231-236. doi: 10.4103/tjo.tjo_80_20. eCollection 2022 Apr-Jun.
Extranodal natural-killer/T-cell lymphoma (ENKTL) is a rare type of non-Hodgkin lymphoma. However, it is common in Asia and South America. ENKTL, nasal type (ENKTL-NT), predominantly presents initial unspecific clinical manifestations involving the nasal cavity and its adjacent structures. We present two cases to increase the awareness of the ENKTL-NT cases masquerading inflammatory processes. Although the main clinical feature is a rapidly progressive facial destruction, none of these patients experienced the mentioned complaint. Its various manifestations frequently lead to misdiagnosis and delayed treatment, particularly in those with marked ocular, not nasal symptoms. Our patients were previously diagnosed with inflammatory conditions, namely sinusitis, idiopathic orbital inflammation, dacryocystitis, and orbital cellulitis. The combined approach of chemotherapy and radiotherapy has been proposed as the treatment of choice. Both cases showed young adults treated with combined therapy, yet showing poor outcomes. Clinicians should be aware of its existence and have to consider ENKTL-NT as one of the differential diagnoses in sinonasal or orbital inflammatory cases with unusually rapid progression or unresponsive to treatment.
结外自然杀伤细胞/ T细胞淋巴瘤（ENKTL）是一种罕见的非霍奇金淋巴瘤。然而，它在亚洲和南美洲较为常见。鼻型结外自然杀伤细胞/ T细胞淋巴瘤（ENKTL-NT）主要表现为涉及鼻腔及其相邻结构的初始非特异性临床表现。我们报告两例病例，以提高对伪装成炎症过程的ENKTL-NT病例的认识。尽管主要临床特征是快速进展的面部破坏，但这些患者均未出现上述症状。其各种表现常常导致误诊和治疗延迟，尤其是在那些有明显眼部而非鼻部症状的患者中。我们的患者之前被诊断为炎症性疾病，即鼻窦炎、特发性眼眶炎症、泪囊炎和眼眶蜂窝织炎。化疗和放疗联合治疗已被提议作为首选治疗方法。两例病例均为年轻成年人，接受联合治疗，但预后不佳。临床医生应意识到其存在，并必须将ENKTL-NT视为鼻窦或眼眶炎症病例中进展异常迅速或对治疗无反应的鉴别诊断之一。
