Nahir A M
Cell Biochem Funct. 1987 Apr;5(2):109-12. doi: 10.1002/cbf.290050205.
Cartilage generally is one of those tissues that exhibit aerobic glycolysis. In a previous study on rat epiphyseal cartilage it had been suggested that this phenomenon is related to potentially excessive production of pyruvate and acetyl coenzyme A, the latter derived from fatty acid oxidation and inhibiting pyruvate dehydrogenase activity. The present study has shown that, in human articular cartilage, the contribution from fatty acid oxidation is too small to account for this phenomenon although the total potential production of pyruvate could still be in excess of the requirements for acetyl coenzyme A for the Krebs' cycle. Of greater relevance may be the apparent correlations that have been found between the activities of lactate and glyceraldehyde 3-phosphate dehydrogenases (r = 0 X 82: 0.01 greater than p greater than 0.001) and between those of lactate and glucose 6-phosphate dehydrogenases (r = 0.92; p less than 0.001).
软骨通常是那些表现出有氧糖酵解的组织之一。在先前一项关于大鼠骨骺软骨的研究中，有人提出这种现象与丙酮酸和乙酰辅酶A的潜在过量产生有关，后者源自脂肪酸氧化并抑制丙酮酸脱氢酶活性。本研究表明，在人类关节软骨中，尽管丙酮酸的总潜在产量可能仍超过三羧酸循环中乙酰辅酶A的需求，但脂肪酸氧化的贡献过小，无法解释这一现象。更具相关性的可能是已发现的乳酸脱氢酶和3-磷酸甘油醛脱氢酶活性之间的明显相关性（r = 0.82；0.01＞p＞0.001）以及乳酸脱氢酶和6-磷酸葡萄糖脱氢酶活性之间的明显相关性（r = 0.92；p＜0.001）。
