Department of Histopathology, Rizgary Teaching Hospital, Erbil, Iraq.
Department of Basic Sciences/Pathology, College of Medicine, Hawler Medical University, Erbil, Iraq.
J Med Life. 2022 May;15(5):679-684. doi: 10.25122/jml-2021-0244.
Gastric adenocarcinoma is a malignant neoplasm of the gastric mucosa composed of neoplastic cells and supporting stroma as with any neoplasm. Stromal myofibroblasts have an essential role in creating the tumor-promoting environment. They express certain substances, such as CD10. In this study, stromal CD10 expression was investigated by immunohistochemistry in gastric carcinoma, and its association with specific clinicopathological parameters was analyzed. Formalin-fixed paraffin-embedded blocks of 80 gastric adenocarcinoma cases were collected retrospectively in a private laboratory of the Rizgary Teaching Hospital for 2 years (January 2018-January 2020). Finally, the immunohistochemical study of CD10 expression in stromal cells was performed. According to the results, stromal CD10 immunoreactivity was detected in 15% of the cases. Furthermore, a statistically significant correlation was observed between stromal CD10 and the tumor type (P=0.015). However, no statistically significant relationship was identified between stromal CD10 expression and patients' age, gender, lymphovascular invasion, lymph node status, and tumor stage and grade. The results suggest a statistically significant positive correlation between stromal CD10 expression and tumor type.
胃腺癌是一种恶性肿瘤，由肿瘤细胞和支持间质组成，与任何肿瘤一样。间质肌纤维母细胞在创建促进肿瘤生长的环境中起着重要作用。它们表达某些物质，如 CD10。在这项研究中，通过免疫组织化学方法研究了胃腺癌中间质 CD10 的表达，并分析了其与特定临床病理参数的关系。在私人实验室 Rizgary 教学医院（2018 年 1 月至 2020 年 1 月）回顾性收集了 80 例胃腺癌病例的福尔马林固定石蜡包埋块。最后，对间质细胞中 CD10 表达的免疫组织化学研究。根据结果，在 15%的病例中检测到间质 CD10 免疫反应性。此外，还观察到间质 CD10 与肿瘤类型之间存在统计学显著相关性（P=0.015）。然而，间质 CD10 表达与患者年龄、性别、血管淋巴管浸润、淋巴结状态以及肿瘤分期和分级之间没有统计学显著关系。结果表明，间质 CD10 表达与肿瘤类型之间存在统计学显著正相关。
