Sheppard M S, Minuk G Y, Bhaumick B, Bala R M
Clin Invest Med. 1987 Mar;10(2):49-53.
IGFs are growth hormone-dependent, serum growth factors which are secreted primarily by liver, although other tissues contribute. We have measured IGF levels in serum of patients with primary biliary cirrhosis (n = 28), primary sclerosing cholangitis (n = 10), and alcohol-induced liver disease (n = 16), and compared them to a group of healthy controls (n = 25). Serum IGF-I as measured by radioimmunoassay was significantly decreased in all patient groups to 30% of control. After acid gel chromatography, IGF-II, measured by radioreceptor assay, was slightly decreased (p less than 0.05) in primary sclerosing cholangitis patients, but not in the other liver disease patients, when compared to the controls. The regression of IGF-II vs IGF-I for primary biliary cirrhosis patients was significant, with r = 0.62, p less than 0.01 (n = 27). The mean ratio of IGF-II/IGF-I was significantly different for histologic stage 2 vs stage 3 vs stage 4 primary biliary cirrhosis patients, but stage 2 was not different from control. We suggest low IGF-I values may reflect compromised hepatocyte function, and secretion of IGF-I and IGF-II may be from different cell populations, or controlled by different mechanisms.
胰岛素样生长因子（IGFs）是依赖生长激素的血清生长因子，主要由肝脏分泌，不过其他组织也有分泌。我们检测了原发性胆汁性肝硬化患者（n = 28）、原发性硬化性胆管炎患者（n = 10）和酒精性肝病患者（n = 16）血清中的IGF水平，并将其与一组健康对照者（n = 25）进行比较。通过放射免疫测定法测得的所有患者组血清IGF-I均显著降低至对照的30%。经酸性凝胶色谱法分离后，通过放射受体测定法测得的IGF-II在原发性硬化性胆管炎患者中略有降低（p < 0.05），但与对照组相比，其他肝病患者中未出现此情况。原发性胆汁性肝硬化患者的IGF-II与IGF-I的回归具有显著性，r = 0.62，p < 0.01（n = 27）。原发性胆汁性肝硬化患者组织学2期、3期和4期的IGF-II/IGF-I平均比值存在显著差异，但2期与对照组无差异。我们认为低IGF-I值可能反映肝细胞功能受损，且IGF-I和IGF-II的分泌可能来自不同细胞群体，或受不同机制控制。
