Seitchik J
Clin Obstet Gynecol. 1987 Mar;30(1):42-9. doi: 10.1097/00003081-198703000-00007.
To summarize: Functional dystocia is easily diagnosed in laboring patients by lack of cervical dilatation for 2 hours in association with weak uterine contractions. If the membranes are intact, amniotomy should be performed. If cervical dilatation at a rate of at least 1 cm/h does not occur promptly, oxytocin should be begun. Efficient and safe use of oxytocin requires knowledge of its clinical pharmacologic characteristics: that the maximum level of a dose is not reached for approximately 40 minutes, that the blood level needed is a reflection of the sensitivity of the myometrium, and the blood level produced by a specific dose is a manifestation of the plasma clearance rate. While it has never been demonstrated that continuous electronic monitoring of the uterus and fetus with intermittent visits from professional personnel is better than palpation and auscultation performed by an educated attendant present continuously, the former practice is more common in the United States than the latter. If maximum use is to be made of the information provided by the uterine monitor, the data must be quantitated. When the patient's inadequate contractility fails to improve in response to the initial dose of 1 mU/m, the dose must be increased until some improvement is noted. Geometric incrementation should be limited to nulliparas in whom each dose of oxytocin is evaluated after a 40-minute infusion period.(ABSTRACT TRUNCATED AT 250 WORDS)
在分娩患者中,若宫颈扩张停滞2小时且伴有子宫收缩乏力,则易于诊断为功能性难产。若胎膜完整,应行人工破膜。若宫颈扩张未迅速达到至少每小时1厘米的速度,则应开始使用缩宫素。高效且安全地使用缩宫素需要了解其临床药理学特性:一剂药物的最大血药浓度约40分钟后才能达到,所需血药浓度反映子宫肌层的敏感性,特定剂量产生的血药浓度体现血浆清除率。虽然从未有研究表明专业人员间断性检查下的子宫和胎儿连续电子监护比有经验的护理人员持续进行的触诊和听诊更好,但在美国,前一种做法比后一种更常见。若要充分利用子宫监护仪提供的信息,必须对数据进行量化。当患者收缩力不足对初始剂量1毫单位/分钟无反应时,必须增加剂量直至出现改善。几何级数递增仅适用于初产妇,在每次输注缩宫素40分钟后评估每一剂缩宫素的效果。(摘要截选至250字)