通过 Rh(II)催化的双（重氮）吲哚-2-酮的级联反应，实现导向基控制的稠合吲哚多环化合物的发散合成。
Substrate-directed divergent synthesis of fused indole polycycles through Rh(II)-catalyzed cascade reactions of bis(diazo)indolin-2-ones.
机构信息
College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, China.
Joint National Laboratory for Antibody Drug Engineering, Clinical Laboratory of the First Affiliated Hospital, School of Medicine, Henan University, Kaifeng, 475004, China.
出版信息
Chem Commun (Camb). 2022 Jul 28;58(61):8576-8579. doi: 10.1039/d2cc02686d.
Herein, we report a substrate-directed diverse synthetic strategy toward two kinds of structurally intriguing fused indole polycycles through Rh(II)-catalyzed cascade reactions of bis(diazo)indolin-2-ones with enaminones. The subtle structural changes in enaminones lead to different reactivities. Cyclic enaminones produce indolo[2,3-]indoles, whereas acyclic ones afford oxazolo[3,2-]indoles.
在此，我们报告了一种通过 Rh(II)催化的双（重氮）吲哚-2-酮与烯胺酮的级联反应，实现两种结构有趣的稠合吲哚多环的底物导向的多样化合成策略。烯胺酮的细微结构变化导致了不同的反应性。环状烯胺酮生成吲哚[2,3-a]吲哚，而非环状烯胺酮则生成噁唑[3,2-a]吲哚。
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