Psychiatry and Clinical Psychology Service, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
Universidad de Las Palmas de Gran Canaria (ULPGC), Las Palmas de Gran Canaria, Spain.
Nutr Neurosci. 2023 Aug;26(8):696-705. doi: 10.1080/1028415X.2022.2081448. Epub 2022 Jul 11.
There is substantial evidence supporting that remote interventions are useful to change dietary habits. However, the effect of a remote intervention based on Mediterranean diet (MD) in depressive patients has been less explored.
This study aims to assess the effectiveness of a remotely provided Mediterranean diet-based nutritional intervention in the context of a secondary prevention trial of depression.
The PREDIDEP study was a 2-year multicenter, randomized, single-blinded trial designed to assess the effect of the MD enriched with extra virgin olive oil (EVOO) on the prevention of depression recurrence. The intervention group received usual care for depressed patients and remote nutritional intervention every three months which included phone contacts and web-based interventions; and the control group, usual care. At baseline and at 1-year and 2-year follow-up, the 14-item MD Adherence Screener (MEDAS) questionnaire and a semiquantitative food frequency questionnaire (FFQ) were collected by a dietitian. Mixed effects linear models were used to assess changes in nutritional variables according to the group of intervention. The trial was registered at ClinicalTrials.gov NCT03081065.
Compared with control group, the MD intervention group showed more adherence to MD (between-group difference: 2.76; 95% CI 2.13-3.39; < 0.001); and a healthier diet pattern with a significant increase in the consumption of olive oil ( < 0.001), and a significant reduction in refined cereals ( = 0.031) after 2 years of intervention.
The remote nutritional intervention increases adherence to the MD among recovered depression patients. ClinicalTrials.gov identifier: NCT03081065.
有大量证据表明远程干预有助于改变饮食习惯。然而，基于地中海饮食（MD）的远程干预对抑郁患者的影响尚未得到充分探索。
本研究旨在评估基于地中海饮食的远程营养干预在抑郁症二级预防试验中的有效性。
PREDIDEP 研究是一项为期 2 年的多中心、随机、单盲试验，旨在评估富含特级初榨橄榄油（EVOO）的 MD 对预防抑郁复发的影响。干预组接受了常规的抑郁患者护理和每三个月一次的远程营养干预，包括电话联系和基于网络的干预；对照组则接受常规护理。在基线、1 年和 2 年随访时，营养师收集了 14 项 MD 依从性筛查器（MEDAS）问卷和半定量食物频率问卷（FFQ）。使用混合效应线性模型根据干预组评估营养变量的变化。该试验在 ClinicalTrials.gov 注册，编号为 NCT03081065。
与对照组相比，MD 干预组的 MD 依从性更高（组间差异：2.76；95%CI 2.13-3.39； < 0.001）；并且饮食模式更健康，橄榄油的摄入量显著增加（ < 0.001），精制谷物的摄入量显著减少（ = 0.031），干预 2 年后。
远程营养干预可提高康复后抑郁患者对 MD 的依从性。ClinicalTrials.gov 标识符：NCT03081065。
