A&J Science Co., Ltd., 80 Chumbok Road, Dong Gu, Daegu, 41061, Republic of Korea.
Department of Agricultural Biotechnology, Seoul National University, 1 Gwanak Road, Gwanak-gu, Seoul, 08826, Republic of Korea.
J Nat Prod. 2022 Aug 26;85(8):1928-1935. doi: 10.1021/acs.jnatprod.2c00120. Epub 2022 Jul 11.
infection is a global public health threat. Extensive assays using clinical isolates have identified micrococcin P2 (MP2, ) as a particularly effective anti- agent. MP2 possesses a mode of action that differs from other antibiotics and pharmacokinetic properties that render it especially promising. Its time-kill studies have been investigated using hypervirulent ribotype 027. DSS (dextran sulfate sodium)-induced mouse studies with that strain indicate that is better than vancomycin and fidaxomicin. Thus, micrococcin P2 is a valuable platform to be exploited for the development of new anti- antibiotics.
感染是一个全球性的公共卫生威胁。广泛使用临床分离株进行的研究鉴定出微球菌素 P2（MP2）是一种特别有效的抗菌剂。MP2 具有不同于其他抗生素的作用模式和药代动力学特性，使其具有特别的应用前景。已使用高毒力 027 型核糖体对其杀菌动力学进行了研究。用该菌株进行的 DSS（葡聚糖硫酸钠）诱导的小鼠研究表明，MP2 优于万古霉素和非达霉素。因此，微球菌素 P2 是一个有价值的平台，可以用来开发新的抗菌抗生素。
