Cystic Fibrosis Department, Institute of Mother and Child, Warsaw, Poland; Cystic Fibrosis Centre, Pediatric Hospital, Dziekanów Leśny, Poland.
Cystic Fibrosis Department, Institute of Mother and Child, Warsaw, Poland; Cystic Fibrosis Centre, Pediatric Hospital, Dziekanów Leśny, Poland.
Nutrition. 2022 Oct;102:111725. doi: 10.1016/j.nut.2022.111725. Epub 2022 May 6.
With increasing life expectancy of patients with cystic fibrosis (CF), gastrointestinal manifestations of the disease have been increasingly brought into focus. This was a systematic review of the PubMed database and ongoing phase III clinical trials that aimed to summarize recent (published after June 1 2016) studies reporting the effects of nutritional interventions on anthropometric measures (weight, height, and body mass index) in patients with CF. Two ongoing trials and 40 published studies (18 interventional and 22 observational) were identified. Key results supported the benefits of comprehensive, individualized nutritional plans, high-fat, high-calorie diet including high-quality carbohydrates, and enteric tube feeding (albeit the latter was derived from observational studies only). In contrast, the supplementation of probiotics, lipids, docosahexaenoic, glutathione, or antioxidant-enriched multivitamin appeared to have little effect on anthropometric measures.
随着囊性纤维化 (CF) 患者预期寿命的延长，其胃肠道表现已越来越受到关注。这是对 PubMed 数据库和正在进行的 III 期临床试验的系统回顾，旨在总结最近（发表于 2016 年 6 月 1 日之后）报道营养干预对 CF 患者人体测量指标（体重、身高和体重指数）影响的研究。确定了两项正在进行的试验和 40 项已发表的研究（18 项干预性和 22 项观察性）。主要结果支持综合、个体化营养计划、高脂肪、高热量饮食（包括高质量碳水化合物）和肠内喂养（尽管后者仅来自观察性研究）的益处。相比之下，益生菌、脂质、二十二碳六烯酸、谷胱甘肽或富含抗氧化剂的多种维生素补充剂似乎对人体测量指标没有影响。
