Davis George E, Kemp Scott S
Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida School of Medicine, Tampa, Florida 33612, USA
Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida School of Medicine, Tampa, Florida 33612, USA.
Cold Spring Harb Perspect Med. 2023 Apr 3;13(4):a041156. doi: 10.1101/cshperspect.a041156.
The extracellular matrix represents a critical regulator of tissue vascularization during embryonic development and postnatal life. In this perspective, we present key information and concepts that focus on how the extracellular matrix controls capillary assembly, maturation, and stabilization, and, in addition, contributes to tissue stability and health. In particular, we present and discuss mechanistic details underlying (1) the role of the extracellular matrix in controlling different steps of vascular morphogenesis, (2) the ability of endothelial cells (ECs) and pericytes to coassemble into elongated and narrow capillary EC-lined tubes with associated pericytes and basement membrane matrices, and (3) the identification of specific growth factor combinations ("factors") and peptides as well as coordinated "factor" and extracellular matrix receptor signaling pathways that are required to form stabilized capillary networks.
细胞外基质是胚胎发育和出生后生命过程中组织血管化的关键调节因子。从这个角度来看，我们提供了关键信息和概念，重点关注细胞外基质如何控制毛细血管的组装、成熟和稳定，此外，还有助于组织的稳定性和健康。特别是，我们展示并讨论了以下方面的机制细节：（1）细胞外基质在控制血管形态发生不同步骤中的作用；（2）内皮细胞（ECs）和周细胞共同组装成带有相关周细胞和基底膜基质的细长且狭窄的毛细血管内皮细胞内衬管的能力；（3）确定形成稳定毛细血管网络所需的特定生长因子组合（“因子”）和肽，以及协调的“因子”和细胞外基质受体信号通路。
