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伪装成体位性直立性心动过速综合征的2B型多发性内分泌腺瘤病

MEN2B Masquerading as Postural Orthostatic Tachycardia Syndrome.

作者信息

Khan Ghazi, Giacona John, Mirfakhraee Sasan, Vernino Steven, Vongpatanasin Wanpen

机构信息

Hypertension Section, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

出版信息

JACC Case Rep. 2022 Jul 6;4(13):814-818. doi: 10.1016/j.jaccas.2022.04.009.

DOI:10.1016/j.jaccas.2022.04.009
PMID:35818599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9270602/
Abstract

Multiple endocrine neoplasia type 2B is a genetic disorder characterized by pheochromocytoma, medullary thyroid carcinoma, and marfanoid features. Although hypertension and stress cardiomyopathy are known cardiovascular complications of pheochromocytoma, clinical presentation maybe subtle. Elevation in heart rate and lightheadedness induced by catecholamine excess may mimic clinical features of postural orthostatic tachycardia syndrome, as shown in our case report. ().

摘要

2B型多发性内分泌腺瘤病是一种遗传性疾病,其特征为嗜铬细胞瘤、甲状腺髓样癌和类马凡氏体型外貌。虽然高血压和应激性心肌病是已知的嗜铬细胞瘤心血管并发症,但其临床表现可能不明显。如我们的病例报告所示,儿茶酚胺过量引起的心率升高和头晕可能会模仿体位性直立性心动过速综合征的临床特征。()

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d4/9270602/011d94f0edc3/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d4/9270602/a59aa24771f6/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d4/9270602/16d0a08b0ee5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d4/9270602/334664285885/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d4/9270602/011d94f0edc3/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d4/9270602/a59aa24771f6/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d4/9270602/16d0a08b0ee5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d4/9270602/334664285885/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53d4/9270602/011d94f0edc3/gr3.jpg

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引用本文的文献

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本文引用的文献

1
Evaluation of Survival and Postoperative Radiation Among Patients with Advanced Medullary Thyroid Carcinoma: An Analysis of the National Cancer Database.评估晚期甲状腺髓样癌患者的生存和术后放疗:国家癌症数据库分析。
Ann Surg Oncol. 2022 Apr;29(4):2582-2591. doi: 10.1245/s10434-021-11158-9. Epub 2022 Jan 23.
2
A narrative review of multiple endocrine neoplasia syndromes: genetics, clinical features, imaging findings, and diagnosis.多发性内分泌肿瘤综合征的叙述性综述:遗传学、临床特征、影像学表现及诊断
Ann Transl Med. 2021 Jun;9(11):944. doi: 10.21037/atm-21-1165.
3
Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1.
体位性心动过速综合征(POTS):2019 年美国国立卫生研究院专家共识会议的科学现状和临床护理 - 第 1 部分。
Auton Neurosci. 2021 Nov;235:102828. doi: 10.1016/j.autneu.2021.102828. Epub 2021 Jun 5.
4
MEN2-related pheochromocytoma: current state of knowledge, specific characteristics in MEN2B, and perspectives.与2型多发性内分泌腺瘤(MEN2)相关的嗜铬细胞瘤:知识现状、MEN2B的特殊特征及展望
Endocrine. 2020 Sep;69(3):496-503. doi: 10.1007/s12020-020-02332-2. Epub 2020 May 10.
5
Postural Orthostatic Tachycardia Syndrome: JACC Focus Seminar.体位性心动过速综合征:美国心脏病学会焦点研讨会。
J Am Coll Cardiol. 2019 Mar 19;73(10):1207-1228. doi: 10.1016/j.jacc.2018.11.059.
6
Catecholamine-Induced Cardiomyopathy in Pheochromocytoma: How to Manage a Rare Complication in a Rare Disease?儿茶酚胺诱导性心肌病在嗜铬细胞瘤中的作用:如何应对罕见疾病中的罕见并发症?
Horm Metab Res. 2019 Jul;51(7):458-469. doi: 10.1055/a-0669-9556. Epub 2018 Sep 18.
7
Epidemiology, clinical features, and genetics of multiple endocrine neoplasia type 2B in a complete population.完整人群中2B型多发性内分泌腺瘤病的流行病学、临床特征及遗传学
Oncologist. 2014 Dec;19(12):1284-6. doi: 10.1634/theoncologist.2014-0277. Epub 2014 Oct 29.